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Choosing between CAR T-cell therapy and pirtobrutinib in double-refractory CLL.
Clin Adv Hematol Oncol
December 2024
Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Signless Laplacian energy aware decision making for electric car batteries based on intuitionistic fuzzy graphs.
Sci Prog
January 2024
Department of Mathematics, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Fuzzy graphs (FGs) contain dual-nature characteristics that may be extended to intuitionistic fuzzy graphs. These FGs are better at capturing ambiguity in situations in reality involving decision-making than FGs. In this paper, we address decision-making problems based on intuitionistic fuzzy preference relations (IFPRs) by utilizing Signless Laplacian energy (S), intuitionistic fuzzy weighted averaging (IFWA), and intuitionistic fuzzy weighted averaging geometric (IFWAG).
View Article and Find Full Text PDFCerebral Fat Embolism After Traumatic Long-Bone Fracture: A Case Report.
Clin Case Rep
December 2024
Department of Anaesthesia, Intensive Care and Emergency Policlinico Paolo Giaccone Palermo Italy.
We here describe a rare case of a 26-year-old male patient, presenting to our hospital after a motorcycle-car accident for the surgical management of long-bone fractures to the tibia and femur and shoulder dislocation and undergoing orthopedic surgery, who postoperatively developed seizure, coma, and respiratory failure due to a cerebral fat embolism. After some hours after the surgery, a loss of consciousness was described by caregivers, and the ICU team was alerted, and the patient was admitted to ICU. Intracranial hemorrhage and stroke were subsequently excluded and, finally, a whole-body computed tomography angiography scan and head magnetic resonance imaging showed lesions consistent with cerebral fat embolism.
View Article and Find Full Text PDFChimeric antigen receptor T-cell therapy in autoimmune diseases.
Front Immunol
December 2024
Department of Neurosurgery, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
The administration of T cells that have been modified to carry chimeric antigen receptors (CARs) aimed at B cells has been an effective strategy in treating B cell malignancies. This breakthrough has spurred the creation of CAR T cells intended to specifically reduce or alter the faulty immune responses associated with autoimmune disorders. Early positive outcomes from clinical trials involving CAR T cells that target the B cell protein CD19 in patients suffering from autoimmune diseases driven by B cells have been reported.
View Article and Find Full Text PDFAI-assisted design of lightweight and strong 3D-printed wheels for electric vehicles.
PLoS One
December 2024
Department of Computer Science, University of Zululand, Kwadlangezwa, South Africa.
The automotive industry is undergoing a transformative shift towards electric vehicles (EVs), driven by environmental concerns and technological advancements. One critical aspect of EV design is the development of lightweight yet robust components, including 3D vehicle wheels. This research explores the implementation of generative models in Computer-Aided Design (CAD) systems to optimize the design of 3D vehicle wheels for electric vehicles.
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