Inflammatory Bowel Disease (IBD) is a chronic non-specific disease that affects the gastrointestinal tract, and Intestinal Mucosal Barrier (IMB) damage is closely related to its pathogenesis. The management of IBD often involves repairing the mechanical, chemical, immune, or biological barriers of the intestinal mucosa to alleviate symptoms. Currently, the treatment of IBD patients requires continuous medication or surgical interventions, which can cause irreversible damage to the patient's body over time. Natural flavonoids, commonly found in human diets, offer a safe, effective, and non-toxic alternative, presenting significant potential for promoting intestinal health and disease prevention. This article aimed to explore current research concerning the role of natural flavonoids in modulating the IMB in IBD, offering a new perspective for the prevention and management of IBD and highlighting new opportunities for the development and application of natural flavonoids.
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