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Imiquimod and Lentigo Maligna: Can Severe Inflammation Be the Endpoint in Short-Term Use?
Balkan Med J
January 2025
Department of Dermatology, Ankara University Faculty of Medicine, Ankara, Türkiye.
Lentigo maligna: A retrospective analysis of 50 cases treated with imiquimod monitored with non-invasive reflectance confocal microscopy.
J Eur Acad Dermatol Venereol
December 2024
Dermatology Department, Norfolk & Norwich University Hospital, Norwich, UK.
Cutaneous melanoma in situ: a review.
Clin Exp Dermatol
October 2024
Department of Dermatology, Norfolk and Norwich University Hospital, Norwich, UK.
Cutaneous melanoma in situ (MIS), also known as 'stage 0 melanoma', is a collection of malignant melanocytes in the epidermis and epithelial adnexa, without evidence of microinvasion to the papillary dermis. Distinct histologic subtypes include lentigo maligna (LM), superficial spreading (SS) MIS and acral lentiginous (AL) MIS. LM is the most common subtype, usually diagnosed later in life (median age at diagnosis of 66-72 years) and associated with cumulative ultraviolet radiation exposure.
View Article and Find Full Text PDFLentigo maligna: a comprehensive review on diagnosis and treatment.
Ital J Dermatol Venerol
August 2024
Dermatology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain -
Article Synopsis
- Lentigo maligna (LM) is a type of melanoma in situ that usually develops on sun-damaged skin, appearing as a slow-growing patch, making it tricky to diagnose and treat.
- While LM generally has a good prognosis, it can invade the dermis and behave like invasive melanoma, making surgical removal the primary treatment option.
- New methods such as margin-controlled surgery and image-guided treatments are being explored, alongside other non-surgical options, to better manage LM/LMM and address the challenges of treating lesions in sensitive areas.
Successful implementation of handheld reflectance confocal microscopy as the standard of care in the (surgical) management of lentigo maligna (melanoma).
J Eur Acad Dermatol Venereol
June 2024
Department of Dermatology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Article Synopsis
- Reflectance confocal microscopy (RCM) shows potential in improving surgical outcomes by detecting subclinical melanoma (LM/LMM) before surgery.
- A study involving 117 cases demonstrated that handheld RCM (HH-RCM) identified subclinical LM in 60% of instances, and 27% of cases had changed management plans, often resulting in less extensive surgeries.
- The use of HH-RCM significantly improved histological margin status to 96.5% compared to 81% in historical cases, and it contributed to a much lower local recurrence rate of 1.6%, suggesting its value in tailoring treatment for patients.
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