Effects of warning information at medication initiation on deprescribing intentions in older adults: A hypothetical vignette.

Objectives: To explore to what degree providing patients warning information about the long-term risks of a medication would affect their subsequent desire to discontinue it.

Methods: We conducted a vignette-based online experiment in which participants aged ≥ 65 years from the United States were asked to imagine starting and subsequently stopping omeprazole. Participants were randomized to one of four vignettes about starting omeprazole (potential long-term harms or no harm information; OTC vs. prescription). Participants reported interest in stopping omeprazole on a 6-point Likert scale. We calculated descriptive statistics and used logistic regression to compare participants with high (scores 4-6) versus low agreement (scores 1-3) with stopping.

Results: Participants (n = 1245) had a median age of 70 years. After adjusting for demographic characteristics, older adults who received warning information when starting the medication were more likely to agree to stop omeprazole (OR 1.21, 95 % C.I. 1.02, 1.43). Willingness to stop omeprazole was higher among women (vs. men), among respondents with higher literacy, and among those who had never or previously used PPIs (vs current use).

Conclusion: Warning information about potential long-term risks when initiating a medication may increase the likelihood of subsequently stopping a medication when recommended by a PCP.