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Sophoricoside Inhibited Glioblastoma Cell Progression Through Activated AMP-Activated Protein Kinase (AMPK).
Mol Carcinog
January 2025
Department of Neurosurgery, Huanggang Central Hospital of Yangtze University, Huanggang, China.
Glioblastoma (GBM) is the most common malignant primary brain tumor, with a mean survival of less than 2 years. Unique brain structures and the microenvironment, including blood-brain barriers, put great challenges on clinical drug development. Sophoricoside (Sop), an isoflavone glycoside isolated from seeds of Sophora japonica L.
View Article and Find Full Text PDFChromosome-level genome assembly of Pontederia cordata L. provides insights into its rapid adaptation and variation of flower colors.
DNA Res
January 2025
School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Pontederia cordata L. is an aquatic ornamental plant native to the Americas, but has been widely distributed in South Asia, Australia, and Europe. The genetic mechanisms behind its rapid adaptation and spread have not yet been well understood.
View Article and Find Full Text PDFInterfacial engineering-induced electronic state modulation in Ru/MoS heterostructures for efficient hydrogen evolution reaction.
Chem Commun (Camb)
January 2025
Key Laboratory of Functional Membrane Material and Membrane Technology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, 189 Songling Road, Qingdao, 266101, China.
In traditional binary heterojunction catalysts, mismatched energy band structures lead to higher electron transfer barriers. By reducing the work function difference a ternary Ru-RuS/MoS heterostructure, we developed a HER catalyst with remarkable activity (17 mV@10 mA cm) and excellent stability (300 h@500 mA cm).
View Article and Find Full Text PDFThe Prognostic Value of Peripheral Blood Inflammatory Markers in Hepatocellular Carcinoma Treated with Lenvatinib Combined with PD-1 Inhibitors.
J Hepatocell Carcinoma
January 2025
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, People's Republic of China.
Purpose: To investigate the prognostic value of inflammatory indexes based on peripheral blood cells in unresectable hepatocellular carcinoma (HCC) patients treated with Lenvatinib combined with PD-1 inhibitors.
Methods: This study retrospectively collected baseline inflammatory indexes from HCC patients received Lenvatinib and PD-1 inhibitor-based combination therapy at the Cancer Hospital of the Chinese Academy of Medical Sciences between October 2018 and October 2021. The optimal threshold values for inflammatory indexes determined using X-tile.
Utilizing physiologies, transcriptomics, and metabolomics to unravel key genes and metabolites of Bge. seedlings in response to drought stress.
Front Plant Sci
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Institute of Chinese Materia Medica, Shaanxi Provincial Academy of Traditional Chinese Medicine, Xi'an, Shaanxi, China.
Drought stress inhibits Bunge () seedling growth and yield. Here, we studied the effects of drought stress on the different parts of seedlings through physiological, transcriptomic, and metabolomics analyses, and identified key genes and metabolites related to drought tolerance. Physiological analysis showed that drought stress increased the accumulation of hydrogen peroxide (HO), enhanced the activity of peroxidase (POD), decreased the activity of catalase (CAT) and the contents of chlorophyll b and total chlorophyll, reduced the degree of photosynthesis, enhanced oxidative damage in seedlings, and inhibited the growth of plants.
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