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http://dx.doi.org/10.1016/j.jacadv.2024.101346 | DOI Listing |
Curr Cancer Drug Targets
January 2025
Department of Cardiology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning, China.
Introduction: The cardiotoxicity and subsequent Heart Failure (HF) induced by Doxorubicin (DOX) limit the clinical application of DOX. Valsartan (Val) is an angiotensin II receptor blocker that could attenuate the HF induced by DOX. However, the underlying mechanism of Val in this process is not fully understood.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Department of Pharmaceutics, School of Pharmacy, Ningxia Medical University, No. 1160 Shengli South Street, Yinchuan 750004, PR China.
The structural disruption of intestinal barrier and excessive reactive oxygen/nitrogen species (RONS) generation are two intertwined factors that drive the occurrence and development of ulcerative colitis (UC). Synchronously restoring the intestinal barrier and mitigating excess RONS is a promising strategy for UC management, but its treatment outcomes are still hindered by low drug accumulation and retention in colonic lesions. Inspired by intestine colonizing bacterium, we developed a mucoadhesive probiotic -mimic entinostat-loaded hollow mesopores prussian blue (HMPB) nanotherapeutic (AM@HMPB@E) for UC-targeted therapy via repairing intestinal barrier and scavenging RONS.
View Article and Find Full Text PDFJACC Adv
December 2024
Division of Cardiology, Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA.
Lancet Reg Health Eur
March 2025
Faculty of Pharmacy and Medicine, Sapienza University, Rome, Italy.
Digital technologies can help support the health of migrants and refugees and facilitate research on their health issues. However, ethical concerns include security and confidentiality of information; informed consent; how to engage migrants in designing, implementing and researching digital tools; inequitable access to mobile devices and the internet; and access to health services for early intervention and follow-up. Digital technical solutions do not necessarily overcome problems that are political, social, or economic.
View Article and Find Full Text PDFThe species, valued for their pharmaceutical, ornamental, and economic importance, exhibit notable rarity and endemism in the Karst areas of the Yunnan-Kweichow Plateau in China. These species face significant threats from habitat loss and fragmentation, leading to a decline in biodiversity. To mitigate these threats, the Maxent algorithm was employed to analyze current and future distribution patterns, with a particular focus on the influence of climate variables in predicting potential distribution shifts and assessing extinction risks under the optimistic SSP1-2.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!