Background: Surgical treatment of therapy-resistant radiculopathy associated with lumbar herniated discs in patients with extreme obesity is a challenge for neurosurgeons. In addition to technical problems in surgery due to the abundant subcutaneous adipose tissue and perioperative risks, there are significant anesthetic risks when anesthesia is performed with a patient in the prone position. A surgical procedure should preferably be minimally traumatic and quick with minimal risks of complications. Large studies show good results with minimally invasive techniques, namely microsurgical and endoscopic ones. However, in the case of surgeries in patients with extreme obesity, an endoscopic approach seems to be preferable because the spinal canal is quickly reached through a small skin incision using this approach.
Case Description: We describe in detail the successful surgical treatment of a 48-year-old patient with extreme obesity (body mass index 54.3 kg/m) and therapy-resistant immobilizing radiculopathy at the L4 level on the left by minimally invasive endoscopic sequestrectomy. Following the surgery, the patient was rapidly mobilized and discharged on the 4th postoperative day. No complications were reported in the early and late postoperative periods.
Conclusions: The endoscopic approach can be successfully used for the treatment of therapy-resistant radiculopathy in patients with extreme obesity and can be considered as the main technique of surgical treatment, being both quick and minimally traumatic.
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http://dx.doi.org/10.21037/jss-24-36 | DOI Listing |
Reprod Sci
January 2025
Department of Zoology, Zakir Husain Delhi College (University of Delhi), J.L.N. Marg, New Delhi, 110002, India.
Polycystic Ovary Syndrome (PCOS) is among the most prevalent endocrinological abnormalities of young females, posing a grave public health challenge to the society. The objective of the present literature review is to analyze the enormous amount of information available by way of numerous multi-omic studies, and to explore a meaningful relationship between various factors such as genetic, proteomic, environmental etc. to understand the multifactorial metabolic disorder in a proper manner.
View Article and Find Full Text PDFAm J Perinatol
January 2025
Center for Advanced Research Training and Innovation, Center for Birth Defects Research, University of Maryland School of Medicine, Baltimore, Maryland.
This study aimed to assess the strengths, limitations, opportunities, and threats presented by diabetes-in-pregnancy. We review the improvements in maternal and fetal mortality since the advent of insulin therapy, evaluate current health challenges, and identify opportunities for preventing increased mortality due to diabetes-in-pregnancy. Prior to 1922, women with type 1 diabetes mellitus (T1DM) of childbearing age were discouraged from becoming pregnant as the maternal and fetal/neonatal mortality rates were extremely high.
View Article and Find Full Text PDFPan Afr Med J
January 2025
Service de Gynéco-Obstérique de l'Hôpital de l'Amitié Tchad-Chine, Ndjamena, Tchad.
Introduction: arterial hypertension (AH) may persist beyond three months postpartum after preeclampsia, increasing the long-term risk of cardiovascular complications. The purpose of this study is to describe the epidemiological aspects and factors associated with persistent hypertension following preeclampsia.
Methods: we conducted a longitudinal descriptive study, from January 2022 to June 2023.
Biomedicines
December 2024
1st Department of Obstetrics and Gynecology, 'Alexandra' General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece.
Background/objectives: Severe obesity (BMI > 40 kg/m) has a severe influence on vascular health and reproduction. This study looks at how bariatric surgery affects endothelial nitric oxide synthase (eNOS) expression and reproductive hormone regulation across different follicle-stimulating hormone receptor (FSHR) polymorphism groups in women with extreme obesity.
Methods: Twenty-nine women with extreme obesity had bariatric surgery.
Orthopadie (Heidelb)
January 2025
Klinikum Dortmund, Klinik für Chirurgie, Klinikum der Universität Witten/Herdecke, Beurhausstraße 40, 44137, Dortmund, Deutschland.
Background: Over the past 20 years, surgical treatment of obesity, or metabolic surgery, has established itself as an extremely efficient and sustainable therapy for treating severely overweight patients. Compared to non-surgical weight reduction procedures, surgical techniques have been shown to be superior in all studies, both in terms of short-term and long-term effectiveness. On the other hand, the invasiveness of the procedures is something that many patients view critically.
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