Cementless fixation in total joint arthroplasty: Factors impacting osseointegration.

•The success of cementless fixation in TJA depends on a multitude of factors including biological, mechanical, implant, surgical, and material properties.•Biologic fixation has become the primary mode of fixation for the majority of primary total hip arthroplasty (THA) surgeries done today in the United States (US) due to its low complication rate and superior longevity compared to cemented fixation.•Cementless fixation has yet to gain wider acceptance in total knee arthroplasty (TKA) and hip hemiarthroplasty due to several factors including host bone quality, implant design, and surgical technique.•Understanding a) the properties of the different biomaterials, b) the bone-implant interface characteristics of the different ingrowth and ongrowth surfaces, and c) the various factors that affect osseointegration can lead to:i)appropriate choice of implants for individual patients with consequent increase in revision-free survival, andii)the development of new techniques that can reduce the risk of aseptic loosening.