Introduction: Numerous orthopaedic procedures including dynamic hip screw plating and various osteotomies require placement of a reference guide pin or K wire to direct bone cuts or for drilling screw holes. Appropriate positioning of these wires is a critical component of surgery. Irrespective of whether one is a seasoned surgeon or an apprentice, these wires often need repositioning and readjustment. Parallel wire positioning is needed even during procedures like osteotomies or patellar fracture fixation. Though there are several tools available to help with accurate placement of wires and saving operating time, there are very few tools which can actually control the direction or angulation of the wire. The ones which are available are usually difficult to use, are bulky, have long attachments arms or have too many fine adjustments. We propose a device that not only directs the positioning of the parallel wires but also helps with a 360-degree correction in direction of the wrongly positioned wire. It is a multipurpose jig that can be used in patella fracture, inter-trochanteric fracture femur, fracture neck of femur, osteotomies around knee, elbow and distal femur, etc.
Material And Methods: We proposed, designed and manufactured a new device for the guide wire insertion. Our jig design has three tunnels. Two tunnels, primary and secondary run parallel to each other and the oblique tunnel runs at an angle and is positioned 7 mm away from the parallel tunnel at one end and shares a common opening with the secondary tunnel on opposite end. Other similar jigs either have only parallel tunnels (primary and secondary) or an oblique tunnel which is at the far end of metal bar, making it difficult to be used to correct the angular direction of the guidewire in reference to primary or secondary wire.
Results And Conclusions: Using our newer device, wires can be guided in all directions and in all planes (sagittal, coronal, axial, and 360°). Correction of the wire direction using this jig is significantly easier and faster, a process which can take anywhere between 15 min and an hour of surgical time for a beginner orthopaedic surgeon. The need for multiple repeated attempts to insert wires, resulting in a bone void and damage to the surrounding structures, is minimised or eliminated. Applications include a variety of surgical procedures of osteosynthesis and osteotomies. In conclusion, our device is easier to use as it is smaller in size and available in different sizes and angles. It not only avoids bone loss and fragmentation due to repetitive insertion of wires but also improves the accuracy of primary reference wire placement or revision of its direction.
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http://dx.doi.org/10.1016/j.jcot.2024.102841 | DOI Listing |
Clin Cardiol
January 2025
Unidad de Revisiones Sistemáticas y Meta-análisis (URSIGET), Vicerrectorado de Investigación, Universidad San Ignacio de Loyola, Lima, Peru.
Background: There is scarce data on the prognostic value of frailty in patients with Takotsubo cardiomyopathy (TCM). This study aimed to assess the association between frailty and in-hospital outcomes in patients with TCM.
Methods: Adult admissions with TCM were included using the 2016-2019 National Inpatient Sample database.
Nephrol Dial Transplant
November 2024
Department of Medicine and Nephrology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Background And Hypothesis: Daprodustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, is approved for treatment of anemia in dialysis patients with CKD in some parts of the world. This subgroup analysis examined the efficacy and safety of daprodustat versus darbepoetin alfa in patients with anemia of CKD undergoing peritoneal dialysis (PD).
Methods: ASCEND-D (NCT02879305) was an open-label, Phase 3 trial; patients with CKD were randomized to daprodustat daily and epoetin alfa (HD patients) or darbepoetin alfa (PD patients).
J Pathol Clin Res
January 2025
Department of Urology, University of Duisburg-Essen, Essen, Germany.
Distinct molecular subtypes of muscle-invasive bladder cancer (MIBC) may show different platinum sensitivities. Currently available data were mostly generated at transcriptome level and have limited comparability to each other. We aimed to determine the platinum sensitivity of molecular subtypes by using the protein expression-based Lund Taxonomy.
View Article and Find Full Text PDFAnn Transl Med
December 2024
Post-Graduation Department, Faculty of Medical Sciences of Minas Gerais, Belo Horizonte, Brazil.
Background And Objective: Sarcopenia, characterized by the progressive loss of skeletal muscle mass (MM) and muscle function, is a common and debilitating condition in cancer patients, significantly impacting their quality of life, treatment outcomes, and overall survival. The pathophysiology of sarcopenia is multifactorial, involving metabolic, hormonal, and inflammatory changes. Recent research highlights the role of chronic inflammation in the development and progression of sarcopenia, with pro-inflammatory cytokines being key mediators of muscle catabolism.
View Article and Find Full Text PDFIntroduction: Age-associated depletion in nicotinamide adenine dinucleotide (NAD+) concentrations has been implicated in metabolic, cardiovascular, and neurodegenerative disorders. Supplementation with NAD+ precursors, such as nicotinamide riboside (NR), offers a potential therapeutic avenue against neurodegenerative pathologies in aging, Alzheimer's disease, and related dementias. A crossover, double-blind, randomized placebo (PBO) controlled trial was conducted to test the safety and efficacy of 8 weeks' active treatment with NR (1 g/day) on cognition and plasma AD biomarkers in older adults with subjective cognitive decline and mild cognitive impairment.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!