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Uncommon and Unusual Variants of Autoimmune Bullous Diseases.

Indian Dermatol Online J

August 2024

Department of Dermatology, Venereology and Leprology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Article Synopsis
  • Autoimmune blistering diseases (AIBDs) are skin conditions caused by the body's immune system attacking certain proteins, leading to blister formation, and can be categorized into intraepidermal and subepidermal types.
  • The objective of this review is to raise awareness about rare and uncommon AIBD variants, such as pemphigus herpetiformis and anti-laminin 332 pemphigoid, among others.
  • By discussing these unusual variants, the review aims to assist healthcare professionals in the early diagnosis and treatment of these conditions.
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: Dapsone (DP) is employed in the management of various skin conditions, including autoimmune bullous diseases to non-enzymes (n-eAIBDs). This study aimed to assess the advantages and safety profile of DP treatment in n-eAIBDs patients. The evaluation focused on clinical remission, reduction in glucocorticosteroid (GCS) usage, and adverse incidents during a 12-month observation in a dermatology department at a Central European university.

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Article Synopsis
  • The case involves Brunsting-Perry, which appears as a red, erosive plaque on skin that has been damaged by sun exposure.
  • The condition worsened to include blister formation after extended sun exposure, prompting a reevaluation of the diagnosis.
  • This emphasizes the importance of considering cicatricial pemphigoid in eroded skin lesions that don't show blisters, especially in areas with sun damage.
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