Introduction: Compared to aortic dissection and isolated visceral artery dissection, multiple peripheral arterial dissections have not been formally reported to date. Currently, there is no well-established treatment for this condition, and large-scale studies with extensive sample data are lacking.
Case Presentation: A 56-year-old male, was provisionally diagnosed with " idiopathic multiple peripheral arterial dissections." The patient primarily presented with lower left abdominal pain. Routine abdominal computed tomography (CT) revealed a right internal iliac artery aneurysm. Further evaluation using aortic computed tomography angiography (CTA) revealed multiple peripheral arterial dissections throughout the body. To screen for the same condition in the cervical and intracranial arteries, a comprehensive head and neck CTA was performed, which revealed a left internal carotid artery dissection. Subsequent positron emission tomography-computed tomography (PET-CT) shows increased glucose metabolism in the left external iliac artery, suggesting arterial inflammation. The patient is treated with intravenous methylprednisolone at a dose of 40 mg per day for six days, followed by the addition of intravenous cyclophosphamide at an initial dose of 0.2g, gradually increasing to a maintenance dose of 1.0 g once a month. After six months of treatment, follow-up aortic CTA and head and neck CTA revealed the disappearance of an arc-shaped low-density shadow in the left external iliac artery.
Conclusion: The etiology of idiopathic multiple peripheral arterial dissection remains unclear, and the case is rare. The long-term prognosis requires ongoing follow-up. As research progresses, it may become necessary to reconsider the diagnosis of this disease.
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http://dx.doi.org/10.1016/j.heliyon.2024.e34085 | DOI Listing |
Ann Transl Med
December 2024
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Background: Osteoarthritis (OA) is increasingly thought to be a multifactorial disease in which sustained gut inflammation serves as a continued source of inflammatory mediators driving degenerative processes at distant sites such as joints. The objective of this study was to use the equine model of naturally occurring obesity associated OA to compare the fecal microbiome in OA and health and correlate those findings to differential gene expression synovial fluid (SF) cells, circulating leukocytes and cytokine levels (plasma, SF) towards improved understanding of the interplay between microbiome and immune transcriptome in OA pathophysiology.
Methods: Feces, peripheral blood mononuclear cells (PBMCs), and SF cells were isolated from healthy skeletally mature horses (n=12; 6 males, 6 females) and those with OA (n=6, 2 females, 4 males).
Japanese encephalitis (JE) is a mosquito-borne infectious disease caused by the Japanese encephalitis virus (JEV). There is currently no effective treatment for JE, and all approved Japanese encephalitis vaccine products originated from the JEV genotype III (GIII). In recent years, JEV genotype I (GI) has gradually replaced GIII as the dominant genotype, and a new symptom of peripheral nerve injury (PNI) caused by JEV NX1889 strain has attracted wide attention, in which JEV envelope (E) protein may be involved in early peripheral nerve injury.
View Article and Find Full Text PDFHeliyon
July 2024
Department of Vascular Surgery, the Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.
Introduction: Compared to aortic dissection and isolated visceral artery dissection, multiple peripheral arterial dissections have not been formally reported to date. Currently, there is no well-established treatment for this condition, and large-scale studies with extensive sample data are lacking.
Case Presentation: A 56-year-old male, was provisionally diagnosed with " idiopathic multiple peripheral arterial dissections.
Can J Hosp Pharm
January 2025
, MD, FRCPC, is with the Department of Hematology/Oncology, William Osler Health System, Brampton, Ontario.
Chem Biodivers
January 2025
univ oeb, snv, ali menjli, 25000, constantine, ALGERIA.
This study investigates the pharmaceutical potential both in vitro and in silico of ethanolic propolis extract from three Algerian regions namely TAH (Tahir-Jijel), ATH (Oued Athmania-Mila) and OZ (Oued Zhor-skikda). Twenty-three compounds were identified via HPLC‒DAD, with key constituents including caffeic acid, cynarin, chrysin, naringin, and hesperetin. Moreover, Antioxidant and anti-Alzheimer activities were assessed by multiple assays.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!