Saline-tolerant medicinal plants possess novel chemical constituents with high bioactivity because of their unique secondary metabolic pathways. an aquatic plant found in the coastal wetlands of the Yellow River Delta, was collected and studied in the present work. Ten drimane-type sesquiterpenoids and four triterpenoids, including six new ones (sinenseines A-F), were isolated from a whole plant of for the first time. Their structures, including the absolute configurations, were determined by analyzing the comprehensive spectroscopic data. In addition, twelve terpenoids, including nine sesquiterpenoids, were identified using UPLC-MS/MS and GNPS methods. All isolates were evaluated for their antiproliferative and anti-inflammatory activities. Compounds 2-4, 6, 13, and 14 showed moderate anti-tumor effects on A549, H1299, HepG2 and A2780 cells with IC values ranging from 35.2 ± 2.0 to 90.5 ± 3.1 μM. Furthermore, compound 1 exhibited significant anti-inflammatory activity with an IC value of 8.3 ± 1.2 μM against NO production in LPS-induced RAW 264.7 macrophages.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733673 | PMC |
| http://dx.doi.org/10.1039/d4ra06721e | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Saline-tolerant medicinal plants possess novel chemical constituents with high bioactivity because of their unique secondary metabolic pathways. an aquatic plant found in the coastal wetlands of the Yellow River Delta, was collected and studied in the present work. Ten drimane-type sesquiterpenoids and four triterpenoids, including six new ones (sinenseines A-F), were isolated from a whole plant of for the first time.
View Article and Find Full Text PDFSiccanin-related drimane meroterpenoids: biological activities and synthesis.
Nat Prod Rep
January 2025
State Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, China.
Covering: 1962 to 2023Drimane (hydro)quinones biosynthetically arise from the combination of drimane-type terpenoids with phenols or equivalents. Since the isolation of siccanin in 1962 (structure identified in 1967), over 200 natural drimane (hydro)quinones have been reported. They are widespread with remarkably diverse architectures and biological functions, which are achieved by varying either the drimane subunit, hydroquinone segment, or the fusion types of drimane and hydroquinone segment both of them.
View Article and Find Full Text PDFDrimane sesquiterpene esters produced by Aspergillus insuetus BF-1613 as inhibitors of sterol O-acyltransferase.
J Antibiot (Tokyo)
December 2024
Department of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
A new drimane sesquiterpene ester, designated insuetusolate (1), and four reported ones (2-5) were isolated from a culture broth of Aspergillus insuetus BF-1613. The chemical structure of 1 was elucidated by extensive spectroscopic analyses, including MS and NMR. Compound 1 has a drimane-type sesquiterpene core with a 2'E,4'E,6'E-octatrienoate side chain.
View Article and Find Full Text PDFFirst Investigation of Secondary Metabolites from Reveals Compounds with Inhibitive Effects against Three Phytopathogenic Fungi of Agrarian Crops.
J Agric Food Chem
October 2024
Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Fungal secondary metabolites play a highly significant role in crop protection, which is related to their antifungal activity against agriculturally important phytopathogens. In fact, plant diseases caused by fungi including species belonging to the genera of , , and have become increasingly serious affecting crop yield and quality. Hence, there is increasing awareness by the scientific community of the importance of exploiting fungal products for finding new compounds able to inhibit phytopathogens.
View Article and Find Full Text PDFDiscovery and biosynthesis of bacterial drimane-type sesquiterpenoids from .
Beilstein J Org Chem
April 2024
State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Drimane-type sesquiterpenoids (DMTs) are characterized by a distinctive 6/6 bicyclic skeleton comprising the A and B rings. While DMTs are commonly found in fungi and plants, their presence in bacteria has not been reported. Moreover, the biosynthetic pathways for DMTs have been primarily elucidated in fungi, with identified P450s only acting on the B ring.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!