Single-distance nano-holotomography with coded apertures.

High-resolution phase-contrast 3D imaging using nano-holotomography typically requires collecting multiple tomograms at varying sample-to-detector distances, usually 3 to 4. This multi-distance approach limits temporal resolution, making it impractical for studies. Moreover, shifting the sample complicates reconstruction, requiring precise alignment, registration, and interpolation to correct for shift-dependent magnification on the detector. In response, we propose and validate through simulations a novel, to the best of our knowledge, single-distance approach that leverages coded apertures to structure beam illumination while the sample rotates. This approach relies on a joint reconstruction scheme, which integrates phase retrieval with 3D tomography, ensuring data consistency and achieving artifact-free reconstructions from a single distance, unlocking dynamic experiments.