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Reevaluating Anti-Inflammatory Therapy: Targeting Senescence to Balance Anti-Cancer Efficacy and Vascular Disease.
Arterioscler Thromb Vasc Biol
January 2025
Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston. (B.C.-C., N.A.V.G., N.L.P., L.P.E., V.S.K.S., A.M.O., J.L., G.M., O.H., A.D., S.W.Y., C.A.I., K.C.O.M., S. Kotla, J.-i.A.).
Modulating immune function is a critical strategy in cancer and atherosclerosis treatments. For cancer, boosting or maintaining the immune system is crucial to prevent tumor growth. However, in vascular disease, mitigating immune responses can decrease inflammation and slow atherosclerosis progression.
View Article and Find Full Text PDFResponse: reevaluating the promise: Is primary tumor surgery really the key to survival or just a misinterpretation in de novo stage IV breast cancer?
Expert Rev Anticancer Ther
January 2025
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
Reevaluating the promise: Is primary tumor surgery really the key to survival or just a misinterpretation in de novo stage IV breast cancer?
Expert Rev Anticancer Ther
January 2025
Fondazione Policlinico Universitario Agostino Gemelli IRCCS; Department of Woman and Child Health and Public Health, Università Cattolica del Sacro Cuore; Rome, Italy.
Revisiting the safety limit in magnetic nanoparticle hyperthermia: insights from eddy current induced heating.
Phys Med Biol
January 2025
Department of Physics, Aristotle University of Thessaloniki, University Campus, Thessaloniki, 54124, GREECE.
Magnetic nanoparticle hyperthermia (MNH) emerges as a promising therapeutic strategy for cancer treatment, leveraging alternating magnetic fields (AMFs) to induce localized heating through magnetic nanoparticles (MNPs). However, the interaction of AMFs with biological tissues leads to non-specific heating caused by eddy currents, triggering thermoregulatory responses and complex thermal gradients throughout the body of the patient. While previous studies have implemented the Atkinson-Brezovich limit to mitigate potential harm, recent research underscores discrepancies between this threshold and clinical outcomes, necessitating a re-evaluation of this safety limit.
View Article and Find Full Text PDFCuring cryptoglandular anal fistulas-Is it possible without surgery?
Heliyon
January 2025
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China.
Background: Empirical reviews suggested that cryptoglandular anal fistulas require surgical resolution. However, some reports have indicated the possibility of nonsurgical and conservative treatment, which is discussed in this review.
Methods: This review explores the potential of nonsurgical approaches for curing anal fistulas through bacterial inhibition and immunomodulation.
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