The change of detrusor contractility at 5 years after transurethral resection of the prostate: a single center prospective observational study.

Objective: To prospectively assess the impact of transurethral resection of the prostate (TURP) on detrusor function using pressure flow study (PFS) at 5 years after surgery in a single center prospective non-randomized observational study.

Methods: Sixty consecutive male patients were prospectively enrolled and underwent TURP from November 2014 to November 2018. A questionnaire survey, free uroflowmetry and PFS were performed at baseline, and 6, 24 and 60 months after surgery. We divided the age groups at 70 years and defined the younger group as those younger than 70 years old, and the elderly group as those aged 70 years or older. The primary endpoint was the change of the bladder contractility index (BCI).

Results: Of the 60 patients, 39 completed the protocol. Regardless of age, the bladder outlet obstruction indices at 6, 24, and 60 months after surgery were significantly lower than before surgery (all, p<0.01). Although the BCI did not significantly change during 60 months for the entire group of 39 patients, it was significantly decreased at 60 months (85.6) after surgery compared to before surgery (102) in the elderly group (p=0.02).

Conclusion: We prospectively evaluated detrusor contractility up to 5 years after TURP. It was significantly reduced in the elderly, in spite of which the relief of bladder outlet obstruction was maintained for 5 years after surgery.