Gut know-how: IL-22 from T cells boosts stress resilience.

Immunity

Laboratory of Neuroimmunology, School of Life Sciences, Hangzhou 310030, Zhejiang, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou 310024, Zhejiang, China. Electronic address:

Published: January 2025

Immune activation during sustained stress typically worsens stress-related psychopathology. Whether it can enhance stress resilience remains unclear. In this issue of Immunity, Xia, Lu, Lan et al. uncover an anxiolytic function of intestinal IL-22 pathway, which protects against psychological stress.

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Source
http://dx.doi.org/10.1016/j.immuni.2024.11.022DOI Listing

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