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Biological characteristics, immune infiltration and drug prediction of PANoptosis related genes and possible regulatory mechanisms in inflammatory bowel disease.
Sci Rep
January 2025
Department of Gastroenterology, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha, 410013, Hunan, China.
PANoptosis is one of several modes of programmed cell death (PCD) and plays an important role in many inflammatory and immune diseases. The role of PANoptosis in inflammatory bowel disease (IBD) is currently unknown. Differentially expressed PANoptosis-related genes (DE-PRGs) were identified, and pathway enrichment analyses were performed.
View Article and Find Full Text PDFExploring horizons: expanding nursing education with immersive 360º videos.
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Universidade da Integração Internacional da Lusofonia Afro-Brasileira. Redenção, Ceará, Brazil.
Harnessing Internet Search Data as a Potential Tool for Medical Diagnosis: Literature Review.
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Innovation Horizons, Inc., 2819 27th Street, NW, Washington, DC, US.
Background: Access to accurate medical diagnosis has been hindered by socioeconomic disparities, limited availability of specialized medical professionals, and lack of patient education, among other factors. Inequities in access to high-quality healthcare services exacerbate these challenges, often leading to disparities in health outcomes. Missed or inaccurate diagnoses can lead to delayed or unnecessary treatments, risking worsening of the condition.
View Article and Find Full Text PDFAnatomy-driven segmentation of parafoveal optical coherence tomography (OCT) measures may improve associations with clinical outcomes in multiple sclerosis.
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Jacobs Comprehensive MS Treatment and Research Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.
Background: Previous investigations on optical coherence tomography (OCT) in multiple sclerosis (MS) focused on generalizable macular and peri-papillary regions without considering the anatomic variations of the retinal layer thickness.
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RECQL4 affects MHC class II-mediated signalling and favours an immune-evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma.
Clin Transl Med
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Department of Dermatology and Allergy, University Hospital of Munich, Ludwig-Maximilian-University, Munich, Germany.
Background: Cancer immunotherapy has transformed metastatic cancer treatment, yet challenges persist regarding therapeutic efficacy. RECQL4, a RecQ-like helicase, plays a central role in DNA replication and repair as part of the DNA damage response, a pathway implicated in enhancing efficacy of immune checkpoint inhibitor (ICI) therapies. However, its role in patient response to ICI remains unclear.
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