Objective: Most data published on adolescents living with HIV (ALH) have been collected before the large diffusion of second-generation integrase strand transfer inhibitors (INSTI) among the pediatric population. We analyzed the nationwide ANRS-MIE CO10 Pediatric cohort to assess the changes over time in health and social outcomes of French ALH.
Design: The cohort enrolled children born in France since 1985 and, from 2005, children diagnosed with HIV at ≤13 years, including those born abroad if antiretroviral-naive at first medical care in France.
Methods: Adolescents aged ≥10 years at their last visit were included in this analysis. Their characteristics were compared between three periods of birth (1985-1993, 1994-1999, 2000-2010).
Results: Overall, 529 ALH were included. Their median age at first HAART initiation decreased from 94 to 29 months (p < 0·0001). At the last evaluation, the proportions of ALH receiving HAART, receiving INSTI, having HIV-RNA < 50 copies/mL and having CD4 count ≥500/μL increased over time (p < 0.0001), reaching 98·7%, 53·3%, 81·3% and 85·0%, respectively, for those born in 2000-2010. The proportion of maternal and paternal orphans decreased until 14·4% and 11·0%, respectively, for ALH born recently. Compared to middle adolescents (15-17 years) born in 1994-1999, those born in 2000-2010 demonstrated higher academic success (69·2% versus 42·3%) and less frequent academic failure (4·6% versus 6·2%).
Conclusions: Despite spectacular improvement in their health and immunovirological status, ALH remain vulnerable compared to other French adolescents, with a higher risk of being orphan and/or experiencing academic failure. Specific interventions are required to improve their global quality of life.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/QAD.0000000000004121 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Phenomenological Description of the Experiences of Teenagers With Critically Ill Parents.
J Nurs Res
February 2025
Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
Background: Critical illness not only threatens the life of the patient but also may profoundly impact the lives of their loved ones. For teenagers with a critically ill parent, these impacts may have significant, developmentally impactful effects. A descriptive understanding of these effects may advance scholarly understanding of the challenges these teenagers face.
View Article and Find Full Text PDFMental health challenges and perceptions of stigma among youth living with HIV in Tanzania.
PLoS One
January 2025
Duke Global Health Institute, Durham, North Carolina, United States of America.
Youth living with HIV (YLWH) face psychosocial challenges and HIV-related stigma, which impact adherence to antiretroviral therapy (ART). This study was designed to understand better the change in mental health symptoms and experiences with stigma among YLWH in Tanzania who completed the original pilot Sauti ya Vijana (SYV), a mental health and life skills group intervention. YLWH who completed SYV and demonstrated a change of ≥2 points in either direction on their Patient Health Questionnaire PHQ-9 (depression screener) from baseline to 18 months were purposively sampled.
View Article and Find Full Text PDFExploring child and youth understanding of loneliness through qualitative insights and evaluating loneliness measures considering those lived experiences.
Ann N Y Acad Sci
January 2025
Wolfson Centre for Population Health, Queen Mary University of London, London, UK.
The overall goal of this paper is to enhance the understanding and measurement of loneliness by identifying key experiential characteristics of loneliness in children and adolescents, and determine whether there is a need for refined assessment tools that accurately capture that experience. In Study 1, we synthesized the qualitative research on the child and youth experience of loneliness and found shared characteristics of loneliness, with some differences related to developmental changes (e.g.
View Article and Find Full Text PDFInternal migration and its association with childhood asthma in Ecuador: a cross-sectional study.
Colomb Med (Cali)
January 2025
Universidad Internacional del Ecuador UIDE, School of Medicine, Quito, Ecuador Universidad Internacional del Ecuador Universidad Internacional del Ecuador School of Medicine Quito Ecuador.
Background: Differences in asthma prevalence between urban and rural areas have been observed worldwide. Epidemiological studies in middle- and low-income countries suggest that internal migration processes may partly explain these disparities.
Objective: To investigate the association between internal migration and asthma in children living in transitional areas of Ecuador.
Applying intervention mapping to develop a program for promoting short physical activity breaks during class time in upper secondary schools: the MOVE12 protocol study.
Front Sports Act Living
January 2025
Department of Public Health and Sport Sciences, University of Inland Norway, Elverum, Norway.
Introduction: Physical inactivity is a global health challenge, exacerbated by increased screen time and sedentary behaviors. Enhancing physical activity levels at schools offers a promising approach to promote lifelong healthy habits.
Methods: This protocol paper outlines the MOVE12 pilot study, a 12-week intervention study designed to increase physical activity among Norwegian upper secondary school students through 6-7-min daily MOVE-breaks integrated into lessons.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!