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Turning Stress Into Success-Surgery as Professional Sport.
JAMA Surg
January 2025
The Surgical Sabermetrics Laboratory, Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom.
Neuroprotective role of mirabegron: Targeting beta-3 adrenergic receptors to alleviate ulcerative colitis-associated cognitive impairment.
Biomed Pharmacother
January 2025
Pharmacology, Toxicology and Biochemistry Department, Faculty of Pharmacy, Future University in Egypt (FUE), Cairo, Egypt; Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
While cognitive impairment has been documented in ulcerative colitic patients, the possible influence of central β3-adrenergic receptor (β3-AR) signaling on this extraintestinal manifestation remains unclear. Previously, we identified an imperative role for mirabegron (MA) as an agonist of β3-AR, in decreasing the BACE-1/beta-amyloid (Aβ) cue in the colons of UC rats. Consequently, we investigated its therapeutic potential for alleviating cognitive impairment associated with UC.
View Article and Find Full Text PDFOptimization of cutting temperature and surface roughness in CNC turning of Ti-6Al-4V alloy using response surface methodology.
Heliyon
January 2025
Institute of Energy Engineering, Dhaka University of Engineering & Technology, Gazipur, Bangladesh.
This study investigates the optimization of cutting conditions for machining titanium alloy (Ti-6Al-4V) using Response Surface Methodology (RSM), with the goal of minimizing tool-chip interface temperature and surface roughness. The research focuses on key cutting parameters to investigate the most effective combinations for enhancing surface finish and reducing thermal impact during machining. The present study deals with the dry turning of Ti-6Al-4V alloy with carbide alloy inserts in a way to utilize the Analysis of Variance (ANOVA) to develop predictive models for minimum surface roughness and optimum temperature.
View Article and Find Full Text PDFAfter years of armed conflict in northern Uganda, many local people have turned to Evangelical churches for help with healing and recovery. We observe that the healing practices in these churches encourage particular notions of what the mind is, how the mind works and whether it is bounded or porous to the outside world. In the traditional cultural setting in which these people grew to adulthood, many accept that vengeance can attack supernaturally from without.
View Article and Find Full Text PDFThe hidden cost of illicit trade: Evaluating the physiological health of smuggled European glass eels (Anguilla anguilla).
Sci Total Environ
January 2025
Aquaculture Program, Institute of Agrifood Research and Technology (IRTA), La Ràpita, Spain.
European eel is considered a "critically endangered" species due to its population decline (c.a. 98 %) in all European waters, primarily because human activities.
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