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Detection of anti-neuronal cell-surface antigen antibodies in pediatric patients with acute encephalitis in Japan.
Pediatr Int
January 2025
Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
Baihui-Penetrating-Qubin Acupuncture Attenuates Neurological Deficits Through SIRT1/FOXO1 Reducing Oxidative Stress and Neuronal Apoptosis in Intracerebral Hemorrhage Rats.
Brain Behav
December 2024
Acupuncture and Moxibustion Department, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, P. R. China.
Background: Intracerebral hemorrhage (ICH) is a significant global disease with high mortality and disability. As of now, there is no effective therapy available. Oxidative stress and neuronal apoptosis play essential roles in ICH, determining neuronal survival.
View Article and Find Full Text PDFAutoimmune encephalitis with coexisting antibodies to GABABR, GAD65, SOX1 and Ma2.
BMC Neurol
November 2024
Neurology Center, General Hospital of Ningxia Medical University, Yinchuan, 750004, China.
Background: Autoimmune encephalitis (AE) is a disease caused by an abnormal reaction between the body's autoimmunity and the central nervous system, in which the abnormal immune response targets antigenic components within or on the surface of neuronal cells. The main manifestations are mental and behavioural changes, cognitive impairment, impaired consciousness, seizures, movement disorders, etc. Most cell surface antibodies respond well to immunotherapy, intracellular antibodies, on the other hand, are usually associated with more tumours and are relatively difficult to treat with a poor prognosis.
View Article and Find Full Text PDFThree cases with chronic obsessive compulsive disorder report gains in wellbeing and function following rituximab treatment.
Mol Psychiatry
September 2024
Department of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden.
Immunological aetiology is supported for a subgroup with obsessive compulsive disorder (OCD) and conceptualized as autoimmune OCD. The longitudinal clinical course is detailed for three severely ill cases with OCD and indications of immunological involvement with off-label rituximab treatment every six months. All cases showed clear and sustained gains regarding symptom burden and function for over 2.
View Article and Find Full Text PDFClinical characteristics and long-term outcome of CASPR2 antibody-associated autoimmune encephalitis in children.
Ital J Pediatr
August 2024
Department of Pediatrics, Xiangya Hospital of Central South University, Changsha, 410008, Hunan Province, China.
Background: Contactin-associated protein-2(CASPR2) antibody-associated autoimmune encephalitis(AE) is rare in children. This study aimed to report the clinical characteristics and long-term outcome of CASPR2 autoimmunity in children to expand the disease spectrum.
Methods: Children who were hospitalized in our hospital with clinically suspected AE from May 2015 to April 2022 and underwent neuronal surface antibodies detections were retrospectively analyzed.
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