This paper is dedicated to Martin Kirschner one of the outstanding German surgeons of the first half of this century. Many of the inventions and improvements Kirschner made have stood the test of time till today. It was Kirschner who recommended to stretch the stomach for replacing the oesophagus. He practiced for the first time successfully an embolectomy out of the pulmonary artery (1924!). Kirschner improved the wire traction procedure decisevely. Of the same importance is his literary work.
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Unleashing the potential of eHealth in outpatient cancer care for patients undergoing immunotherapy-a quantitative study considering patients' needs and current healthcare challenges.
Front Digit Health
October 2024
Department of Medical Strategy, Process- and Quality Management, Tuebingen University Hospital, Tuebingen, Germany.
Background: The use of online information and communication is globally increasing in the healthcare sector. In addition to known benefits in other medical fields, possible specific potentials of eHealth lie in the monitoring of oncological patients undergoing outpatient therapy. Specifically, the treatment with immune checkpoint inhibitors (ICI) requires intensive monitoring due to various possible negative side effects.
View Article and Find Full Text PDFInherited Telomere Biology Disorders: Pathophysiology, Clinical Presentation, Diagnostics, and Treatment.
Transfus Med Hemother
October 2024
Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Article Synopsis
- Telomeres protect chromosome ends from damage and shorten with cell division, which can lead to aging-related issues like cell senescence or death when they become critically short.
- Premature aging and severe health complications, such as bone marrow failure and pulmonary fibrosis, can occur due to disorders affecting telomere maintenance, known as telomere biology disorders (TBDs).
- Recognizing congenital causes of bone marrow failure in about 10% of cases is crucial for accurate diagnosis and treatment, emphasizing the need for proper counseling and donor selection for stem cell transplants.
Retrospective study on pomalidomide-PACE as a salvage regimen in aggressive relapsed and refractory multiple myeloma.
Eur J Haematol
October 2024
Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany.
Objectives: Despite major advances in treatment options for multiple myeloma (MM), patients refractory to the main drug classes and those with aggressive, especially extramedullary disease, still face a dismal outcome. For these patients, effective therapeutic options are urgently warranted.
Methods: In this retrospective study, we report on the safety and efficacy of the intensive combination regimen of pomalidomide plus cisplatin, doxorubicin, cyclophosphamide, and etoposide (Pom-PACE) in patients with relapsed refractory MM (RRMM) or plasma cell leukemia (PCL).
Evolutionary trajectories of small cell lung cancer under therapy.
Nature
March 2024
Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
The evolutionary processes that underlie the marked sensitivity of small cell lung cancer (SCLC) to chemotherapy and rapid relapse are unknown. Here we determined tumour phylogenies at diagnosis and throughout chemotherapy and immunotherapy by multiregion sequencing of 160 tumours from 65 patients. Treatment-naive SCLC exhibited clonal homogeneity at distinct tumour sites, whereas first-line platinum-based chemotherapy led to a burst in genomic intratumour heterogeneity and spatial clonal diversity.
View Article and Find Full Text PDFTelomere biology disorders may manifest as common variable immunodeficiency (CVID).
Clin Immunol
December 2023
Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, Albert Ludwigs University of Freiburg, Germany; RESIST Cluster of Excellence 2155 to Hannover Medical School, Satellite Center Freiburg, Germany; Clinic for Rheumatology and Clinical Immunology, Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, Albert Ludwigs University of Freiburg, Germany; DZIF German Center for Infection Research, Satellite Center Freiburg, Germany; CIBSS Centre for Integrative Biological Signaling Studies, Albert Ludwigs University, Germany. Electronic address:
Telomere biology disorders (TBD) are caused by germline pathogenic variants in genes related to telomere maintenance and are characterized by critically short telomeres. In contrast to classical dyskeratosis congenita (DC), which is typically diagnosed in infancy, adult or late onset TBD frequently lack the typical DC triad and rather show variable organ manifestations and a cryptic disease course, thus complicating its diagnosis. Common variable immunodeficiency (CVID), on the other hand, is a primary antibody deficiency (PAD) syndrome.
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