Phytochemical investigation of the leaf extract of Roxb. ex Hornem led to the isolation and identification of two new highly oxygenated cyclohexenes, uvariagrandols A () and B (), together with seven known compounds (-). Their structures were elucidated by spectroscopic methods as well as comparisons made from the literature. The (1,2,3,6) absolute configuration of uvariagrandols A and B was established by the comparison of the experimental and calculated electronic circular dichroism (ECD). (+)-Grandifloracin () displayed cytotoxicity against SW480 and K562 cell lines with IC values of 154.9 and 60.9 μM, respectively. 6-Methoxyzeylenol () had -glucosidase inhibitory activity with the IC value of 34.1 μM.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731232PMC
http://dx.doi.org/10.1016/j.heliyon.2024.e41326DOI Listing

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