Through millions of years of evolution, bones have developed a complex and elegant hierarchical structure, utilizing tropocollagen and hydroxyapatite to attain an intricate balance between modulus, strength, and toughness. In this study, continuous fiber silk composites (CFSCs) of large size are prepared to mimic the hierarchical structure of natural bones, through the inheritance of the hierarchical structure of fiber silk and the integration with a polyester matrix. Due to the robust interface between the matrix and fiber silk, CFSCs show maintained stable long-term mechanical performance under wet conditions. During degradation, this material primarily undergoes host cell-mediated surface degradation, rather than bulk hydrolysis. We demonstrate significant capabilities of CFSCs in promoting vascularization and macrophage differentiation toward repair. A bone defect model further indicates the potential of CFSC for bone graft applications. Our belief is that the material family of CFSCs may promise a novel biomaterial strategy for yet to be achieved excellent regenerative implants.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732114PMC
http://dx.doi.org/10.1016/j.bioactmat.2024.11.036DOI Listing

Publication Analysis

Top Keywords

fiber silk
16
hierarchical structure
12
silk composites
8
mechanically robust
4
robust surface-degradable
4
surface-degradable implant
4
fiber
4
implant fiber
4
silk
4
composites demonstrates
4

Similar Publications

Through millions of years of evolution, bones have developed a complex and elegant hierarchical structure, utilizing tropocollagen and hydroxyapatite to attain an intricate balance between modulus, strength, and toughness. In this study, continuous fiber silk composites (CFSCs) of large size are prepared to mimic the hierarchical structure of natural bones, through the inheritance of the hierarchical structure of fiber silk and the integration with a polyester matrix. Due to the robust interface between the matrix and fiber silk, CFSCs show maintained stable long-term mechanical performance under wet conditions.

View Article and Find Full Text PDF

Digest: Evolution of dragline silk in araneids show super tensile performance in web-building and non-web-building spiders.

Evolution

January 2025

School of Environmental and Life Sciences (SELS), Faculty of Science and Health, University of Portsmouth, United Kingdom.

Wolff (2024) takes a comparative phylogenetic approach to study the evolution of dragline silk in 164 species of spiders, including both araneid and non-araneid species. Many structural and mechanical properties of dragline silk showed no correlations; however, both tensile strength and toughness correlated with birefringence-an indicator for the directional ordering of protein materials in the silk fibre. These properties do not seem to differ between web-building and non-web-building spiders; many spider families were found to include species that produce super-performing silk as well as species that produce weak-performing silk.

View Article and Find Full Text PDF

Sutures from natural and synthetic materials are utilized to close wounds, stop bleeding, reduce pain and infection, repair cutaneous wounds, minimize scarring, and promote optimal wound healing. We used mechanical and chemical methods to extract cellulose fibers from cylindrical snake grass (Dracaena angolensis) (Welw. ex Carrière) Byng & Christenh.

View Article and Find Full Text PDF

Holocellulose nanofibrils biomimetic entrapment of liquid metal enable ultrastrong, tough, and lower-voltage-driven paper device.

Carbohydr Polym

March 2025

Beijing Key Laboratory of Lignocellulosic Chemistry, MOE Engineering Research Center of Forestry Biomass Materials and Energy, Beijing Forestry University, Beijing 100083, China; State Key Laboratory of Efficient Production of Forest Resources, Beijing 100083, China. Electronic address:

Integrating liquid metal (LM) with wood fibers for flexible paper electronics is intriguing yet extremely challenging due to poor mechanical performance. Here, we disclose a hemicellulose trapping strategy to achieve exceptional ultrastrong and tough LM-based paper electronics. Holocellulose nanofibrils (HCNFs) with hemicellulose retention of approximately 20 % are found to effectively entrap nanoscale LM within the fibril network, analogous to spider silk capturing small water droplets.

View Article and Find Full Text PDF

Mulberry silk (Bombyx mori) and eri silk (Samia/Philosamia ricini) are widely used silks. Eri silk is a wild silk that contains an arginine-glycine-aspartic acid tripeptide sequence within its structure, making it a potential and sustainable biomaterial. However, its poor solubility using conventional methods has resulted in limited research compared with that of mulberry silk fibroin.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!