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Response to Downie et al.
J Inherit Metab Dis
January 2025
Heidelberg University, Medical Faculty of Heidelberg, Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
Letter to the editor in response to Betzler et al.
J Inherit Metab Dis
January 2025
Victorian Clinical Genetics Service, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Changes to inflammatory markers during 5 years of viral suppression and during viral blips in people with HIV initiating different integrase inhibitor based regimens.
Front Immunol
November 2024
Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH, United States.
Background: Heightened levels of inflammatory markers are linked to increased morbidity/mortality in people with HIV (PWH) and often remain elevated after virologic suppression by antiretroviral therapy (ART). As new combinations of ART become available, an evaluation of their effects on immune activation and inflammation is warranted. Additionally, it remains unknown whether transient increases in viral load ("blips") during ART are associated with increases in inflammation.
View Article and Find Full Text PDFRedefining our vision: an updated guide to the ocular immune system.
Nat Rev Immunol
December 2024
Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Balanced immune responses in the eyes are crucial to preserve vision. The ocular immune system has long been considered distinct, owing to the so-called 'immune privilege' of its component tissues. More recently, intravital imaging and transcriptomic techniques have reshaped scientific understanding of the ocular immune landscape, such as revealing the specialization of immune cell populations in the various tissues of the eye.
View Article and Find Full Text PDFPathogen-Agnostic Advanced Molecular Diagnostic Testing for Difficult-to-Diagnose Clinical Syndromes-Results of an Emerging Infections Network Survey of Frontline US Infectious Disease Clinicians, May 2023.
Open Forum Infect Dis
August 2024
Office of Public Health Data, Surveillance and Technology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Article Synopsis
- * A survey of 643 infectious disease providers revealed that 74% had used advanced molecular testing recently, with 16S rRNA gene sequencing being the most common method employed.
- * Major barriers to using these tests included the lack of national guidelines and high costs, but there's potential for improvement in clinical practice and public health with better access and clear protocols.
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