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Biomarker-guided antibiotic stewardship in neonatology: time for implementation?
Pediatr Res
January 2025
Dept of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial.
JAMA
December 2024
Warwick Medical School, Clinical Trials Unit, University of Warwick, Coventry, United Kingdom.
Importance: For hospitalized critically ill adults with suspected sepsis, procalcitonin (PCT) and C-reactive protein (CRP) monitoring protocols can guide the duration of antibiotic therapy, but the evidence of the effect and safety of these protocols remains uncertain.
Objective: To determine whether decisions based on assessment of CRP or PCT safely results in a reduction in the duration of antibiotic therapy.
Design, Setting, And Participants: A multicenter, intervention-concealed randomized clinical trial, involving 2760 adults (≥18 years), in 41 UK National Health Service (NHS) intensive care units, requiring critical care within 24 hours of initiating intravenous antibiotics for suspected sepsis and likely to continue antibiotics for at least 72 hours.
Biomarker-Guided Antibiotic Discontinuation in Adults Critically Ill With Sepsis: Harnessing Network Meta-Analysis to Guide Clinical Therapy.
Crit Care Med
October 2024
Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.
Biomarker guided antibiotic stewardship in community acquired pneumonia: A randomized controlled trial.
PLoS One
August 2024
Department of Pulmonary Medicine, Northwest Hospital, Alkmaar, the Netherlands.
Background: In community-acquired pneumonia (CAP), the role of biomarkers to shorten duration of antibiotic treatment has not been firmly established. We assessed the effectiveness of active feedback of treatment algorithms based on procalcitonin (PCT) and C-reactive protein (CRP), compared to standard care, on the duration of antibiotic treatment in patients hospitalized with community-acquired pneumonia (CAP) in non-ICU wards.
Methods And Findings: We performed a randomised, open label, parallel group, multi-centre trial in 3 Dutch teaching hospitals.
Inflammatory biomarker-based clinical practice in patients with pneumonia: A systematic review of randomized controlled trials.
Rom J Intern Med
September 2024
1Department of Internal Medicine, University Hospital of Patras, Patras, Greece.
Unlabelled: Biomarker-based clinical practice is currently gaining ground and increasingly affects decision making. A variety of biomarkers have been studied through the years and some of them have already an established role in modern medicine, such as procalcitonin (PCT) which has been proposed to reduce antibiotic exposure. We purposed to systematically review all biomarkers examined for guiding the clinical practice in patients with pneumonia.
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