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Advantage of spirometry over oscillometry to detect dupilumab's effect on small airway dysfunction.
Allergol Int
January 2025
Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
Correlation of Two-Minute and Six-Minute Walk Tests With Spirometric Indices in Patients With Severe Chronic Obstructive Pulmonary Disease at a Selected Tertiary Care Hospital in Puducherry.
Cureus
November 2024
Pulmonary Medicine, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, IND.
Background Chronic obstructive pulmonary disease (COPD) is a progressive respiratory condition characterised by airflow limitation and reduced exercise capacity. The Six-Minute Walk Test (6MWT) and Two-Minute Walk Test (2MWT) are commonly used to assess functional exercise capacity in COPD patients. This study aims to evaluate the correlation between the distance covered in the 2MWT and 6MWT with spirometric indices (such as Forced Expiratory Volume in 1 second (FEV₁), Forced Vital Capacity (FVC), and FEV₁/FVC) in COPD patients.
View Article and Find Full Text PDFAn update on multiple breath washout in children with cystic fibrosis.
Expert Rev Respir Med
December 2024
Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Introduction: Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the CF transmembrane regulator (CFTR) gene, leading to progressive lung disease and systemic complications. Lung disease remains the primary cause of morbidity and mortality, making early detection of lung function decline crucial. The Lung Clearance Index (LCI), derived from the multiple breath washout (MBW) test, has emerged as a sensitive measure for identifying early airway disease.
View Article and Find Full Text PDFComparison of Race-neutral Versus Race-specific Spirometry Equations for Evaluation of Child Asthma.
Am J Respir Crit Care Med
December 2024
University of Wisconsin-Madison, Pediatrics, Madison, Wisconsin, United States.
Rationale: Race-based estimates of pulmonary function in children could influence the evaluation of asthma in children from racial and ethnic minoritized backgrounds.
Objectives: To determine if race-neutral (GLI-Global) versus race-specific (GLI-Race-Specific) reference equations differentially impact spirometry evaluation of childhood asthma.
Methods: The analysis included 8,719 children aged 5 to <12 years from 27 cohorts across the United States grouped by parent-reported race and ethnicity.
Effect of pulmonary rehabilitation on all-cause mortality in patients with chronic respiratory disease: a retrospective cohort study in an Australian teaching hospital.
BMC Pulm Med
October 2024
Institute for Breathing and Sleep, Austin Hospital, Heidelberg, VIC, Australia.
Article Synopsis
- A retrospective cohort study analyzed 20-year mortality rates among chronic respiratory disease patients who participated in pulmonary rehabilitation (PR) compared to matched controls, hypothesizing that PR improves long-term survival.
- The study included 238 individuals in the PR program versus an equal number of controls, assessing demographics, clinical variables, and mortality outcomes using statistical analyses like Kaplan-Meier and Cox regression.
- Results showed higher mortality risks in controls (HR=1.64) and revealed that patients in the PR program potentially had lower mortality compared to those not in PR, despite some limitations in the study's methodology.
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