A woman in her early 20s presented with progressive low back pain, leg weakness and sphincter dysfunction. MRI revealed a 5 × 1.5 cm intramedullary tumour at the T12-L2 level. Elevated preoperative beta-human chorionic gonadotropin levels were noted. Surgical excision confirmed the diagnosis of a germinoma. Postoperative MRI showed no additional lesions. The patient underwent localized radiation therapy, but recurrence was noted 10 months later.
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http://dx.doi.org/10.1136/bcr-2024-263168 | DOI Listing |
J Magn Reson Imaging
January 2025
Department of Radiology, Peking University Third Hospital, Beijing, China.
Background: The spinal column is a frequent site for metastases, affecting over 30% of solid tumor patients. Identifying the primary tumor is essential for guiding clinical decisions but often requires resource-intensive diagnostics.
Purpose: To develop and validate artificial intelligence (AI) models using noncontrast MRI to identify primary sites of spinal metastases, aiming to enhance diagnostic efficiency.
Cochrane Database Syst Rev
January 2025
Department of Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
Rationale: Osteoporosis is an abnormal reduction in bone mass and bone deterioration, leading to increased fracture risk. Alendronate belongs to the bisphosphonate class of drugs, which inhibit bone resorption by interfering with the activity of osteoclasts (bone cells that break down bone tissue). This is an update of a Cochrane review first published in 2008.
View Article and Find Full Text PDFGlobal Spine J
January 2025
NYU Langone Health, New York, NY, USA.
Study Design: cross-sectional survey.
Objectives: To evaluate AO Spine members' practices and comfort in managing metastatic and primary spine tumors, explore the use of decision-support and patient assessment tools, and identify knowledge gaps and future needs in spine oncology.
Methods: An online survey was distributed to AO Spine members to query comfort levels with key decisions in spinal oncology management, utilization of decision frameworks and spine oncology-specific instruments, and educational material preferences.
Cureus
December 2024
Orthopedics, Hospital Putrajaya, Putrajaya, MYS.
Introduction Lumbar pyogenic spondylodiscitis is a challenging and rare spinal infection with high morbidity, particularly in patients with comorbidities. While the extreme lateral interbody fusion (XLIF) technique is established in treating degenerative spinal conditions, its efficacy in managing spondylodiscitis is less well-studied. This study aims to evaluate the clinical and radiographic outcomes of the XLIF approach combined with posterior instrumentation in patients with lumbar spondylodiscitis.
View Article and Find Full Text PDFPhys Ther Res
October 2024
Department of Physical Therapy, Faculty of Health and Medical Care, Saitama Medical University, Japan.
Objective: In this study, we aimed to determine the effects of 2-week neuromuscular electrical stimulation (NMES) on quadriceps muscle atrophy and lower extremity motor score in individuals with subacute incomplete cervical spinal cord injury (SCI).
Methods: This stratified randomized controlled trial, conducted in the advanced critical care center of a university hospital, comprised 49 individuals with American Spinal Injury Association (ASIA) impairment scale grade C and D incomplete cervical SCI. The participants were stratified based on the ASIA impairment scale grade and randomly assigned to the control (n = 25) or NMES (n = 24) group.
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