Objectives: This study aimed to measure the psychometrics qualities of an extended model of the Theory of Planned Behavior (TPB) applied to plasma donation, and its relevance in the evaluation of interventions aiming at converting whole-blood donors (WBD) to plasma donation.
Methods: Two studies were conducted. The first (N = 433) compared the efficacy of two communication strategies (standard strategy centered on motivations to donate vs. experimental strategy centered on barriers to donate) for influencing specific determinants of the extended model of the TPB and for engaging WBD in plasma donation. The second study (N = 309) evaluated the gain of adding to the experimental strategy an implementation intentions protocol to facilitate the behavior.
Results: Study 1 showed the relevance of the extended model as a measurement tool of intention's determinants, and the efficacy of the experimental strategy compared to the standard approach to bolster intention, F(2,430) = 7.03, p < 0.001, partial η = 0.032, and to increase the likelihood of commitments χ2(2, N = 433) = 11.904, p = 0.003, Cramer's V = 0.17. Study 2 replicated these results but did not demonstrate any effect of the implementation intentions protocol to strengthen the intervention, χ(1, N = 188) = 1.341, p = 0.25.
Conclusions: These studies showed that addressing barriers to donation is an efficient communication and recruitment strategy. We encourage blood collection agencies to develop communication campaigns in this direction rather than focusing on donors motivations.
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http://dx.doi.org/10.1016/j.tracli.2025.01.003 | DOI Listing |
Acc Chem Res
January 2025
Molecular Sensing and Imaging Center, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
ConspectusIons are the crucial signaling components for living organisms. In cells, their transportation across pore-forming membrane proteins is vital for regulating physiological functions, such as generating ionic current signals in response to target molecule recognition. This ion transport is affected by confined interactions and local environments within the protein pore.
View Article and Find Full Text PDFFASEB J
January 2025
Department of Medicine, Hematology and Oncology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Nuclear factor of activated T-cells 5 (NFAT5) is a transcription factor known for its role in osmotic stress adaptation in the renal inner medulla, due to the osmotic gradient that is generated between the renal cortex and renal inner medulla. However, its broader implications in kidney injury and chronic kidney disease (CKD) are less understood. Here we used two different Cre deleter mice (Ksp1.
View Article and Find Full Text PDFMol Divers
January 2025
Department of Biophysics, Panjab University, Chandigarh, 160014, India.
Alzheimer's disease (AD) is a degenerative neurological disorder defined by the formation of β-amyloid (Aβ) plaques and neurofibrillary tangles within the brain. Current pharmacological treatments for AD only provide symptomatic relief, and there is a lack of definitive disease-modifying therapies. Chemical chaperones, such as 4-Phenylbutyric acid (4PBA) and Tauroursodeoxycholic acid, have shown neuroprotective effects in animal and cell culture models.
View Article and Find Full Text PDFInfect Dis (Lond)
January 2025
Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain.
Background: Multidrug-resistant bacteria (MDR) represent a significant global health concern and vary in specific settings. Spain reported several annual deaths attributed to MDR bacteria, mainly carbapenemase-producing Enterobacterales.
Objectives: We aimed to characterise the incidence and temporal trends of MDR bacterial infections or colonisations reported within the province of Granada (data from five hospitals), and to investigate factors linked to clinical vulnerability.
ACS Chem Neurosci
January 2025
School of Molecular and Life Sciences, Faculty of Science and Engineering, Curtin University, Bentley, WA 6845, Australia.
Natural aging is associated with mild memory loss and cognitive decline, and age is the greatest risk factor for neurodegenerative diseases, such as Alzheimer's disease. There is substantial evidence that oxidative stress is a major contributor to both natural aging and neurodegenerative disease, and coincidently, levels of redox active metals such as Fe and Cu are known to be elevated later in life. Recently, a pronounced age-related increase in Cu content has been reported to occur in mice and rats around a vital regulatory brain region, the subventricular zone of lateral ventricles.
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