To effectively address the contamination caused by antibiotic misuse, this study was conducted to enhance the removal of amoxicillin (AMX) and penicillin sodium (PEN) by incorporating black soldier fly larvae (BSFL). The results showed that BSFL increased the degradation rates of AMX and PEN to 71.00 % and 80.89 %, respectively, and shortened their half-lives to 238 h and 160 h. Proteobacteria (26.2 %-82.0 %), Firmicutes (13.3 %-54.0 %), Acinobacteriota (2.1 %-23.4 %), and Bacteroidota (1.3 %-10.1 %) were the intestinal dominant microorganisms during transformation. Five bacteria with β-lactam antibiotic resistance in the BSFL gut were isolated, among which Morganella morganii demonstrated strong antibiotic tolerance and high removal rates of AMX and PEN in both in vitro and in vivo experiments, ranging from 58.99 % to 95.87 %. BSFL intestinal bacteria disrupted the quaternary pharmacophore of AMX and PEN, breaking them down into at least seven and five metabolites, respectively.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.biortech.2025.132067 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pathway of typical β-Lactam antibiotics degradation by black soldier fly and response characteristic of its intestinal microbes.
Bioresour Technol
January 2025
State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan 430062 China. Electronic address:
To effectively address the contamination caused by antibiotic misuse, this study was conducted to enhance the removal of amoxicillin (AMX) and penicillin sodium (PEN) by incorporating black soldier fly larvae (BSFL). The results showed that BSFL increased the degradation rates of AMX and PEN to 71.00 % and 80.
View Article and Find Full Text PDFShort Variable Regions flaA Gene (SVR-flaA) Diversity and Virulence Profile of Multidrug-Resistant Campylobacter from Poultry and Poultry Meat in India.
J Food Prot
July 2024
Campylobacter Laboratory, Division of Veterinary Microbiology & Immunology, FVSC &A.H Shuhama (Aulesteng) SKUAST-K, J&K 190006, India.
Human gastrointestinal infections caused by Campylobacter species is the second most important foodborne illness after salmonellosis worldwide. Poultry represent one of the main sources of Campylobacter organisms. In the present study, the short variable region of flagellin gene (SVR-flaA) typing was carried out to determine the variation among the circulating strains of Campylobacter jejuni and Campylobacter coli.
View Article and Find Full Text PDFUHPLC-MS/MS Analysis of Antibiotics Transfer and Concentrations in Porcine Oral Fluid after Intramuscular Application.
Pharmaceuticals (Basel)
February 2022
Goodvalley Agro S.A., Dworcowa 25, 77-320 Przechlewo, Poland.
The monitoring of antibiotic use in animals is a crucial element to ensure food safety. The main goal of this study was to analyse the distribution of selected antibiotics to porcine oral fluid, as well as to demonstrate that an oral fluid is an alternative to other biological matrices used in the control of antibacterials. Therefore, an animal study with pigs treated using seven different antibiotics was performed.
View Article and Find Full Text PDFEffects of Antibiotic Use on Saliva Antibody Content and Oral Microbiota in Sprague Dawley Rats.
Front Cell Infect Microbiol
April 2022
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China.
Antibiotics are often used to treat systemic diseases not associated with the oral cavity. This application of antibiotics may affect the healthy oral microbiota community, as it destroys the balance between specific bacterial populations throughout the ecosystem and may lead to dysbacteriosis. We hypothesized that the effects on antibiotics on oral microbiota regulation and function would affect antibody content in saliva, depending on the antibiotic type.
View Article and Find Full Text PDFThe potential application of bio-based ceramic/organic xerogel derived from the plant sources: A new green adsorbent for removal of antibiotics from pharmaceutical wastewater.
J Hazard Mater
May 2022
Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran. Electronic address:
A bio-based ceramic/organic xerogel (BCO-xerogel) was obtained from the combination of sugarcane bagasse ash, polyvinyl alcohol, and pine cone-derived tannin extract, which are abundant, non-toxic, and renewable sources. The as-prepared BCO-xerogel was used as a low-cost green adsorbent for the eliminate of four types of the most widely used antibiotics, including amoxicillin (AMX), tetracycline (TC), cefalexin (CLX), and penicillin G (PEN G) residuals from contaminated water. The simultaneous effects conventional variables including adsorbent dosage, antibiotic concentrations, solution pH, and contact time were studied and optimized by central composite design (CCD) under response surface methodology (RSM).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!