The aim of this study is to conduct a comprehensive bibliometric analysis of CT-based adipose tissue imaging related to coronary artery disease (CAD) to investigate the dynamic development of this field. Web of Science Core Collection was used as our data source to identify relevant documents limited to articles or review articles and written in English with no time restrictions. Then we analyzed the whole trend of publications and utilized VOSviewer and Bibliometrix to conduct a bibliometric analysis including citations, keywords, countries, institutions, authors as well as co-citation analyses of cited references and sources. A total of 629 documents including 560 articles and 69 reviews from 1992 to 2023 were included. The trend of publications was divided into 3 phases and overall exhibited a constant rise. Based on the co-occurrence network of keywords analysis, 3 clusters centered on visceral, epicardial, pericoronary adipose tissue respectively and 1 cluster related to cardiovascular risk factors were identified, meanwhile determining the evolution of fat research. Co-citation analysis suggested that sources were divided into metabolism-related and cardiovascular-related journals. The USA ranked first with 228 documents and 12,086 citations among 47 countries and 1002 institutions, both at the author and institutional levels. In conclusion, this study demonstrated the thriving research field of the impact of CT-based adipose tissue assessment on coronary artery disease, offering a better understanding of the current state of research and valuable insights for future studies and collaborations.
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http://dx.doi.org/10.1097/MD.0000000000040592 | DOI Listing |
Life Metab
December 2024
Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
Type 2 diabetes mellitus (T2DM) is closely associated with obesity, while interactions between the two diseases remain to be fully elucidated. To this point, we offer this perspective to introduce a set of new insights into the interpretation of T2DM spanning the etiology, pathogenesis, and treatment approaches. These include a definition of T2DM as an energy surplus-induced diabetes characterized by the gradual decline of β cell insulin secretion function, which ultimately aims to prevent the onset of severe obesity through mechanisms of weight loss.
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February 2025
Hubei Key Laboratory of Cell Homeostasis, Department of Biochemistry, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Graphical Abstract Lipoprotein lipase (LPL) mediates peripheral tissue triglyceride (TG) uptake. Hepatic ANGPTL3 (A3) and ANGPTL8 (A8) form a complex and inhibit LPL activity in the white adipose tissue (WAT) via systematic circulation. ANGPTL4 (A4) is expressed in WAT and inhibits LPL activity locally.
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February 2025
Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Institutes of Biomedical Sciences, Fudan University, Shanghai 200438, China.
Abdominal aortic aneurysm (AAA) is strongly correlated with obesity, partially due to the abnormal expansion of abdominal perivascular adipose tissue (PVAT). Cell death-inducing DNA fragmentation factor-like effector C (CIDEC), also known as fat-specific protein 27 (FSP27) in rodents, is specifically expressed in adipose tissue where it mediates lipid droplet fusion and adipose tissue expansion. Whether and how CIDEC/FSP27 plays a role in AAA pathology remains elusive.
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December 2023
Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital, Shanghai 200233, China.
Life Metab
December 2023
National Clinical Research Center for Metabolic Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Regardless of its anatomical site, adipose tissue shares a common energy-storage role but exhibits distinctive properties. Exploring the cellular and molecular heterogeneity of white adipose tissue (WAT) is crucial for comprehending its function and properties. However, existing single-nucleus RNA sequencing (snRNA-seq) studies of adipose tissue heterogeneity have examined only one or two depots.
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