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http://dx.doi.org/10.1093/treephys/tpaf005 | DOI Listing |
Sci Rep
January 2025
Department of Basic Sciences, Faculty of Dentistry, Universidad de Antioquia U de A, Medellín, 050010, Colombia.
The NLRP3 inflammasome, regulated by TLR4, plays a pivotal role in periodontitis by mediating inflammatory cytokine release and bone loss induced by Porphyromonas gingivalis. Periodontal disease creates a hypoxic environment, favoring anaerobic bacteria survival and exacerbating inflammation. The NLRP3 inflammasome triggers pyroptosis, a programmed cell death that amplifies inflammation and tissue damage.
View Article and Find Full Text PDFEur J Heart Fail
January 2025
Jesselson Integrated Heart Centre, Shaare Zedek Medical Center, Hebrew University, Jerusalem, Israel.
Aims: To evaluate the association between transcatheter edge-to-edge repair (TEER) and outcomes in patients with significant mitral regurgitation (MR) following acute myocardial infarction (MI), focusing on the aetiology of acute post-MI MR in high-risk surgical patients.
Methods And Results: The International Registry of MitraClip in Acute Mitral Regurgitation following Acute Myocardial Infarction (IREMMI) includes 187 patients with severe MR post-MI managed with TEER. Of these, 176 were included in the analysis, 23 (13%) patients had acute papillary muscle rupture (PMR) and 153 (87%) acute secondary MR.
Tree Physiol
January 2025
Department of Biology, California State University Bakersfield, USA.
J Phys Condens Matter
January 2025
School of Physical Sciences, NISER, Jatni, Bhubaneswar, 752050, INDIA.
We study topological charge pumping (TCP) in the Rice-Mele (RM) model with irreciprocal hopping. The non-Hermiticity gives rise to interesting pumping physics, owing to the presence of skin effect and exceptional points. In the static one-dimensional (1D) RM model, we find two independent tuning knobs that can drive the topological transition, namely, non-Hermitian parameter $\gamma$ and system size $N$.
View Article and Find Full Text PDFPrehosp Emerg Care
January 2025
Department of Emergency Medicine, University of Michigan Medical School, Ann Arbor, Michigan.
Objectives: Out-of-hospital cardiac arrest (OHCA) victims receiving defibrillation from an automated external defibrillator (AED) placed early in the chain of survival are more likely to survive. We sought to explore the accuracy of AED pad placement for lay rescuers (LR) and first responders (FR).
Methods: We conducted a secondary analysis of data collected during randomized OHCA simulation trials involving LRs and FRs.
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