There has been considerable interest in the recent advances in synthetic micro/nanomotors in diverse biofluids due to their potential biomedical applications. However, the propulsion of existing micro/nanomotor platforms for delivery in the gastrointestinal (GI) tract is inefficient. Herein, we present a magnetically and chemically actuated micromotor-tableted pill that can be actively retained in the GI tract . A drug-loaded and water-powered magnesium Janus micromotor enveloped in an enteric polymer-protected magnetic pill was stable in the stomach. The movement of the micromotor pill (MP) was promoted using an external gradient alternating magnetic field with low frequency toward the targeted regions in the intestines. An alternating magnetic field with high frequency induces intensive water-powered propulsion of the micromotors though a magnetocaloric effect, and thus effectively prolongs retention in the intestines. The integration of the newly developed MP system enables active retention of micromotors and promises active drug delivery for GI therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d4tb01712a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dual-responsive micromotor pill for targeted retention in the intestines .
J Mater Chem B
January 2025
Department of General Surgery, Heilongjiang Provincial Hospital, Harbin, China.
There has been considerable interest in the recent advances in synthetic micro/nanomotors in diverse biofluids due to their potential biomedical applications. However, the propulsion of existing micro/nanomotor platforms for delivery in the gastrointestinal (GI) tract is inefficient. Herein, we present a magnetically and chemically actuated micromotor-tableted pill that can be actively retained in the GI tract .
View Article and Find Full Text PDFA Microstirring Oral Pill for Improving the Glucose-Lowering Effect of Metformin.
ACS Nano
May 2023
Department of Nanoengineering and Chemical Engineering, University of California San Diego, La Jolla, California 92093, United States.
Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia due to persistent insulin resistance, resulting in elevated blood glucose levels. Metformin is the most prescribed oral drug for lowering high blood glucose levels in T2DM patients. However, it is poorly absorbed and has low bioavailability.
View Article and Find Full Text PDFZinc Microrocket Pills: Fabrication and Characterization toward Active Oral Delivery.
Adv Healthc Mater
September 2020
Department of Nanoengineering, Chemical Engineering Program, University of California San Diego, La Jolla, CA, 92093, USA.
Here the fabrication of a zinc (Zn) microrocket pill is reported, and its unique features toward active and enhanced oral delivery application are demonstrated. By loading Zn-based tubular microrockets into an orally administrable pill formulation, the resulting Zn microrocket pill can rapidly dissolve in the stomach, releasing numerous encapsulated Zn microrockets that are instantaneously activated and then propel in the gastric fluid. The released Zn microrockets display efficient propulsion without being affected by the presence of the inactive excipient materials of the pill.
View Article and Find Full Text PDFMicromotor Pills as a Dynamic Oral Delivery Platform.
ACS Nano
August 2018
Department of Nanoengineering , University of California San Diego, La Jolla , California 92093 , United States.
Tremendous progress has been made during the past decade toward the design of nano/micromotors with high biocompatibility, multifunctionality, and efficient propulsion in biological fluids, which collectively have led to the initial investigation of in vivo biomedical applications of these synthetic motors. Despite these recent advances in micromotor designs and mechanistic research, significant effort is needed to develop appropriate formulations of micromotors to facilitate their in vivo administration and thus to better test their in vivo applicability. Herein, we present a micromotor pill and demonstrate its attractive use as a platform for in vivo oral delivery of active micromotors.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!