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A sterol panel for rare lipid disorders: sitosterolemia, cerebrotendinous xanthomatosis, and Smith-Lemli-Opitz syndrome.
J Lipid Res
November 2024
Lipid Clinic, Oslo University Hospital, Aker, Oslo, Norway; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Article Synopsis
- Patients with rare lipid disorders have specific sterols that accumulate in their blood, making accurate measurement crucial for diagnosis and treatment monitoring.
- Existing methods to test sterols can be complicated and time-consuming, limiting access to tests in many areas.
- A new, simple method using isotope-dilution LC-MS/MS was developed to quickly extract and measure sterols in blood, validated through analysis of serum samples from both healthy controls and patients, showing significant differences in sterol levels linked to various disorders.
Synthesis of a Side Chain Alkyne Analogue of Sitosterol as a Chemical Probe for Imaging in Plant Cells.
Biomolecules
April 2024
Department of Pharmacy, Ludwig-Maximilians University Munich, Butenandtstraße 5-13, 81377 Munich, Germany.
Clickable chemical tools are essential for studying the localization and role of biomolecules in living cells. For this purpose, alkyne-based close analogs of the respective biomolecules are of outstanding interest. Here, in the field of phytosterols, we present the first alkyne derivative of sitosterol, which fulfills the crucial requirements for such a chemical tool as follows: very similar in size and lipophilicity to the plant phytosterols, and correct absolute configuration at C-24.
View Article and Find Full Text PDFXuanfei Formula inhibited RSV infection by normalizing the SREBP2-mediated cholesterol synthesis process.
Front Microbiol
May 2024
Clinical Laboratory, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background And Aims: Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infections in children and the elderly, often progressing to pneumonia and severe sequelae. However, there are currently no feasible and cost-effective interventions with proven efficacy for children, making medications with anti-RSV activity urgently needed. Traditional Chinese medicine has shown promising therapeutic efficacy in alleviating viral infection symptoms.
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