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| http://dx.doi.org/10.1002/iid3.70125 | DOI Listing |
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is dispensable for zygotic genome activation but essential for morula development.
Science
October 2024
Department of Developmental and Stem Cell Biology, Institut Pasteur, Université Paris Cité, CNRS UMR3738, Epigenomics, Proliferation, and the Identity of Cells Unit, 75015 Paris, France.
Early embryogenesis is driven by transcription factors (TFs) that first activate the zygotic genome and then specify the lineages constituting the blastocyst. Although the TFs specifying the blastocyst's lineages are well characterized, those playing earlier roles remain poorly defined. Using mouse models of the TF , we show that embryos arrest at the early morula stage and exhibit altered lineage specification, frequent mitotic failure, and substantial chromosome segregation defects.
View Article and Find Full Text PDFCommon variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women.
Sci Rep
October 2022
Department of Biology, University of Pisa, 56126, Pisa, Italy.
Article Synopsis
- * Researchers conducted a two-phase study with over 12,000 female participants focusing on single nucleotide polymorphisms (SNPs) related to hormone pathways, finding 14 significant associations initially, but none were validated in the replication phase.
- * Though the study didn't confirm the influence of common polymorphisms on PDAC risk tied to hormone pathways, it did validate a link between variants in the NR5A2 gene and increased PDAC risk.
Liver receptor homolog 1 (LRH-1) regulates follicle vasculature during ovulation in mice.
Reproduction
December 2022
Centre de Recherche en Reproduction et Fertilité, Université de Montréal, St-Hyacinthe, Quebec, Canada.
In Brief: It is well-established that liver receptor homolog 1 (LRH-1/NR5A2) regulates the ovarian function and is required for ovulation and luteinization in mice. In the present experiment, we showed that LRH-1 is required to control vascular changes during ovulation, a novel mechanism of action of this orphan nuclear receptor.
Abstract: Liver receptor homolog 1 (LRH-1/NR5A2) is a key regulator of ovarian function, and recently, it has been suggested that it may regulate changes in follicular angiogenesis, an important event during the ovulatory process and luteal development.
Orphan nuclear receptors in angiogenesis and follicular development.
Reproduction
August 2021
Centre de Recherche en Reproduction et Fertilité, Université de Montréal, St-Hyacinthe, Quebec, Canada.
Orphan nuclear receptors (ONRs) are a subset of the nuclear receptor family that lacks known endogenous ligands. Among 48 nuclear receptors identified in humans, 25 are classified as ONRs. They function as transcription factors and control the expression of a wide range of genes to regulate metabolism, fertility, immunity, angiogenesis, and many other functions.
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