Working toward Personalized Intervention Advice: A Survey Study on Preference Heterogeneity in Patients with Breast Cancer-Related Fatigue.

Unlabelled: Many breast cancer survivors experience cancer-related fatigue (CRF), and several interventions to treat CRF are available. One way to tailor intervention advice is based on patient preferences. In this study, we explore preference heterogeneity regarding between-attribute and within-attribute preferences. In addition, we propose simple decision rules to match preferences to interventions. Nine attributes were included with dichotomized levels. Participants selected their preferred level per attribute and ranked the attributes using best-worst scaling. Between-attribute and within-attribute preferences were determined, together with their heterogeneity. Using decision rules, matching scores were calculated for a hypothetical intervention. Sixty-seven breast cancer survivors completed the survey. They were on average 52 y old, 4.5 y after diagnosis, experienced CRF (6.5-7.2/10) on 3 dimensions (physical, mental, and emotional), and 43% already followed an intervention for CRF. Overall, participants ranked highest. Next to , and were also frequently ranked first. Only 13 participants (19%) shared the most common preference pattern of shorter interventions, daily sessions, shorter session time, a psychosocial intervention, no anonymity, and contact with a therapist and peers. Matching scores for a hypothetical intervention with attributes corresponding with the overall within-attribute preferences varied from 44% to 100%. A large heterogeneity in preferences of breast cancer survivors for CRF intervention attributes was demonstrated. Using simple decision rules, the effect of this heterogeneity on linking preferences to interventions with matching scores was demonstrated. Personalization of intervention advice is necessary due to preference heterogeneity. Tailored advice can result in higher involvement of patients in decision making, intervention adherence and satisfaction, and subsequently a potential higher quality of life after breast cancer.

Highlights: Many breast cancer survivors experience cancer-related fatigue for which many interventions exist.Our results show large preference heterogeneity in breast cancer patients' preferences for attributes of eHealth interventions.Based on this preference heterogeneity, intervention advice for cancer-related fatigue after breast cancer can be personalized, ultimately improving quality of life after breast cancer.