While various methods are employed to ensure the virus safety of finished products, virus filtration (VF) stands out as the preferred method for virus removal and purification of a wide variety of products owing to its capability of separating product molecules with more than 90% recovery and no change in molecule characteristics. The modeling of the virus removal process for VF membranes is based on the principles of microfiltration (MF) and ultrafiltration (UF), but with modifications for the much narrower separation difference, which is less than 2-fold for the separation of product molecules and virus particles. In this review, we introduce the materials and application of VF highlighting the unique characteristics properties of VF membranes through the steps of invention and subsequent development. We examine the virus removal mechanism and filtration models for VF to reproduce and predict the filtration behavior and virus reduction.
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| http://dx.doi.org/10.1016/j.isci.2024.111533 | DOI Listing |
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Ralph E. Martin Department of Chemical Engineering, University of Arkansas, Fayetteville, AR 72701, USA.
While various methods are employed to ensure the virus safety of finished products, virus filtration (VF) stands out as the preferred method for virus removal and purification of a wide variety of products owing to its capability of separating product molecules with more than 90% recovery and no change in molecule characteristics. The modeling of the virus removal process for VF membranes is based on the principles of microfiltration (MF) and ultrafiltration (UF), but with modifications for the much narrower separation difference, which is less than 2-fold for the separation of product molecules and virus particles. In this review, we introduce the materials and application of VF highlighting the unique characteristics properties of VF membranes through the steps of invention and subsequent development.
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