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Phase separation-based screening identifies arsenic trioxide as the N-Myc-DNA interaction inhibitor for neuroblastoma therapy.
Cancer Lett
January 2025
Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, China; Nanhu Brain-computer Interface Institute, Hangzhou 311100, China; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China; School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China; Cancer Center, Zhejiang University, Hangzhou, 310058, China. Electronic address:
Highly Efficient Chiral Separation Based on Alkali-proof Protein Immobilization by Covalent Organic Frameworks.
Angew Chem Int Ed Engl
November 2024
Key Laboratory of Biopharmaceutical Preparation and Delivery, State Key Laboratory of Biochemical Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
Chiral separation plays a pivotal role in both practical applications and industrial productions. However, traditional chiral stationary phases (CSPs) exhibit inherent instability in alkaline environments, presenting a significant challenge despite their importance. Herein, basophilic alcalase is creatively developed to fabricate ultrastable protein-based CSPs that can efficiently work under alkaline conditions.
View Article and Find Full Text PDFDesigning a Refined Multi-Structural Polymer Electrolyte Framework for Highly Stable Lithium-Metal Batteries.
Angew Chem Int Ed Engl
September 2024
State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Electrochemical Process and Technology of Materials, Beijing University of Chemical Technology, Beijing, 100029, P.R. China.
Rational structural designs of solid polymer electrolytes featuring rich interface-phase morphologies can improve electrolyte connection and rapid ion transport. However, these rigid interfacial structures commonly result in diminished or entirely inert ionic conductivity within their bulk phase, compromising overall electrolyte performance. Herein, a multi-component ion-conductive electrolyte was successfully designed based on a refined multi-structural polymer electrolyte (RMSPE) framework with uniform Li solvation chemistry and rapid Li transporting kinetics.
View Article and Find Full Text PDFPhase separation of phospho-HDAC6 drives aberrant chromatin architecture in triple-negative breast cancer.
Nat Cancer
November 2024
Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Article Synopsis
- Dysregulated liquid-liquid phase separation (LLPS) in triple-negative breast cancer (TNBC) is linked to altered chromatin structure, specifically through the action of phosphorylated histone deacetylase 6 (phospho-HDAC6).
- The study reveals that phospho-HDAC6 forms condensates in the nucleus that disrupt normal chromatin architecture, affecting processes like transcriptional regulation.
- Nexturastat A was identified as a potential therapeutic agent that disrupts these phospho-HDAC6 condensates, thereby suppressing tumor growth and restoring proper chromatin organization in TNBC cells.
Development of a Dual Reporter System to Simultaneously Visualize Ca Signals and AMPK Activity.
ACS Sens
September 2024
BioTechMed Graz, Mozartgasse 12/2, Graz 8010, Austria.
In this study, we introduce a new separation of phases-based activity reporter of kinase (SPARK) for AMP-activated kinase (AMPK), named AMPK-SPARK, which reports the AMPK activation by forming bright fluorescent clusters. Furthermore, we introduce a dual reporter system, named GCaMP-AMPK-SPARK, by incorporating a single-fluorescent protein (FP)-based Ca biosensor, GCaMP6f, into our initial design, enabling simultaneous monitoring of Ca levels and AMPK activity. This system offers the essential quality of information by single-channel fluorescence microscopy without the need for coexpression of different biosensors and elaborate filter layouts to overcome spectral limitations.
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