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Harmonized Cognitive Assessment Protocol in the English Longitudinal Study of Ageing: Contrasting approaches to evaluation of factor structure.
Int Psychogeriatr
February 2025
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Center on Aging and Health, Johns Hopkins University, Baltimore, MD, USA. Electronic address:
Objectives: Cognitive theories and previous research on cognitive performance suggest a hierarchical pattern of interrelationships among cognitive tests, but the psychometric properties of the same tests may change when adapted for a different context or applied to a different population. We evaluated the factor structure of a cognitive battery of tests using an exploratory, data-driven approach and a confirmatory, theory-driven approach.
Design: We estimated exploratory factor analyses (EFA) and confirmatory factor analysis (CFA).
Tale of Two n-Backs: Diverging Associations of Dorsolateral Prefrontal Cortex Activation With n-Back Task Performance.
J Neurosci Res
February 2025
Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.
In studying the neural correlates of working memory (WM) ability via functional magnetic resonance imaging (fMRI) in health and disease, it is relatively uncommon for investigators to report associations between brain activation and measures of task performance. Additionally, how the choice of WM task impacts observed activation-performance relationships is poorly understood. We sought to illustrate the impact of WM task on brain-behavior correlations using two large, publicly available datasets.
View Article and Find Full Text PDFHypogonadism in a Man With Cystic Fibrosis and an Unusually Low Serum Testosterone: A Cautionary Tale.
AACE Clin Case Rep
October 2024
Division of Endocrinology, Metabolism, and Lipids, Emory University School of Medicine, Atlanta, Georgia.
Background/objective: Men with cystic fibrosis (CF) have a high prevalence of low testosterone levels. A recent retrospective study demonstrated a quarter of a cohort of men with CF had serum testosterone levels below 300 ng/dL. The evaluation of hypogonadism is of increasing clinical importance in order to prevent unfavorable outcomes.
View Article and Find Full Text PDFTale of two zones: investigating the clinical outcomes and research gaps in peripheral and transition zone prostate cancer through a systematic review and meta-analysis.
BMJ Oncol
April 2024
Translational Oncogenomics, Cancer Research UK Manchester Centre, The University of Manchester, Manchester, UK.
Objective: To assess pathological characteristics, clinical features and outcomes of patients diagnosed with peripheral zone (PZ) and transition zone (TZ) prostate cancer after prostatectomy.
Methods And Analysis: We systematically reviewed PubMed, EMBASE and MEDLINE. Primary endpoints were biochemical relapse-free survival (bRFS) and distant metastases rate; secondary endpoints included clinical and pathological features.
A Tale of 2 Cohorts: Differences in PARTNER 3 Populations.
Ann Thorac Surg
March 2025
Department of Cardiovascular and Thoracic Surgery, West Virginia University, 1 Medical Center Way, Morgantown, WV 26501. Electronic address:
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