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Toxins from Animal Venoms as a Potential Source of Antimalarials: A Comprehensive Review.
Toxins (Basel)
June 2023
Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69040-000, Brazil.
Malaria is an infectious disease caused by spp. and it is mainly transmitted to humans by female mosquitoes of the genus . Malaria is an important global public health problem due to its high rates of morbidity and mortality.
View Article and Find Full Text PDFTowards a method for cryopreservation of mosquito vectors of human pathogens.
Cryobiology
April 2021
Department of Biomedical Sciences, Animal Reproduction and Biotechnology Laboratory, Colorado State University, Fort Collins, CO, USA. Electronic address:
Mosquito-borne diseases are responsible for millions of human deaths every year, posing a massive burden on global public health. Mosquitoes transmit a variety of bacteria, parasites and viruses. Mosquito control efforts such as insecticide spraying can reduce mosquito populations, but they must be sustained in order to have long term impacts, can result in the evolution of insecticide resistance, are costly, and can have adverse human and environmental effects.
View Article and Find Full Text PDFUltraconserved Non-coding DNA Within Diptera and Hymenoptera.
G3 (Bethesda)
September 2020
Neural Cell-Fate Determinants Section.
This study has taken advantage of the availability of the assembled genomic sequence of flies, mosquitos, ants and bees to explore the presence of ultraconserved sequence elements in these phylogenetic groups. We compared non-coding sequences found within and flanking developmental genes to homologous sequences in and Many of the conserved sequence blocks (CSBs) that constitute -regulatory DNA, recognized by alignment protocols, are also conserved in and Also conserved is the position but not necessarily the orientation of many of these ultraconserved CSBs (uCSBs) with respect to flanking genes. Using the mosquito algorithm, we have also identified uCSBs shared among distantly related mosquito species.
View Article and Find Full Text PDFStructural and Functional Analysis of PGRP-LC Indicates Exclusive Dap-Type PGN Binding in Bumblebees.
Int J Mol Sci
April 2020
Key Laboratory for Insect-Pollinator Biology of the Ministry of Agriculture and Rural Affairs, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China.
Peptidoglycan recognition proteins (PGRPs) play an important role in the defense against invading microbes via the recognition of the immunogenic substance peptidoglycan (PGN). Bees possess fewer PGRPs than and but retain two important immune pathways, the Toll pathway and the Imd pathway, which can be triggered by the recognition of Dap-type PGN by PGRP-LCx with the assistance of PGRP-LCa in . There are three isoforms of PGRP-LC including PGRP-LCx, PGRP-LCa and PGRP-LCy in .
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