Background: The Global Matrix initiative provides unique insights into child and adolescent physical activity (PA) worldwide, yet requires substantial human efforts and financial support.
Purpose: This study aimed to evaluate the process and outcomes of the latest edition of the initiative, the Global Matrix 4.0, reflect on its evolution from earlier editions, and provide recommendations for future Global Matrices.
Methods: The evaluation followed a predetermined plan, which included collecting and analyzing qualitative and quantitative data from 3 online surveys to participants and online user activity metrics from MailChimp reports and Google Analytics.
Results: Global Matrix 4.0 participants (57 teams, 682 experts) assessed the PA status in their country/jurisdiction on at least 10 PA indicators and submitted 570 grades for global comparisons. Surveys were completed by 97% to 100% of targeted respondents and demonstrated predominantly high satisfaction rates (>80%) with participation, outputs, and project management. Lack of funding and inadequate national PA data availability were the commonly reported concerns. Suggestions for improvement included amending indicators' benchmarks and expanding the scope of the initiative to early years, underrepresented populations, and additional indicators.
Conclusions: This evaluation process revealed the positive experience of Global Matrix 4.0 participants and the successful delivery of expected outcomes. Reviewing the core set of indicators and benchmarks, expanding the initiative's scope, and fundraising efforts are recommended to further optimize the use of resources and maximize impact.
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http://dx.doi.org/10.1123/jpah.2024-0513 | DOI Listing |
Lancet Microbe
December 2024
Jenner Institute, University of Oxford-NIHR Oxford Biomedical Research Centre, Oxford, UK. Electronic address:
Background: Malaria remains a substantial public health burden among young children in sub-Saharan Africa and a highly efficacious vaccine eliciting a durable immune response would be a useful tool for controlling malaria. R21 is a malaria vaccine comprising nanoparticles, formed from a circumsporozoite protein and hepatitis B surface antigen (HBsAg) fusion protein, without any unfused HBsAg, and is administered with the saponin-based Matrix-M adjuvant. This study aimed to assess the safety and immunogenicity of the malaria vaccine candidate, R21, administered with or without adjuvant Matrix-M in adults naïve to malaria infection and in healthy adults from malaria endemic areas.
View Article and Find Full Text PDFBackground: The Global Matrix initiative provides unique insights into child and adolescent physical activity (PA) worldwide, yet requires substantial human efforts and financial support.
Purpose: This study aimed to evaluate the process and outcomes of the latest edition of the initiative, the Global Matrix 4.0, reflect on its evolution from earlier editions, and provide recommendations for future Global Matrices.
Mol Biol Rep
January 2025
Institute of Health Sciences, Department of Medical and Surgical Research, Hacettepe University, Ankara, Turkey.
Background: La-related protein 7 (LARP7) is a key regulator of RNA metabolism and is thought to play a role in various cellular processes. LARP7 gene autosomal recessive mutations are the cause of Alazami syndrome, which presents with skeletal abnormalities, intellectual disabilities, and facial dysmorphisms. This study aimed to determine the role of LARP7 in modulating gene expression dynamics during osteogenesis.
View Article and Find Full Text PDFVet Res Commun
January 2025
Faculty of Medical Technology, Prince of Songkla University, Songkhla, 90110, Thailand.
Staphylococcus pseudintermedius is a global animal pathogen. Traditional identification methods are time-consuming necessitating a more efficient approach. This study validated and enhanced the loop-mediated isothermal amplification (LAMP) technique by integration it with a lateral flow dipstick (LFD) assay for the detection of S.
View Article and Find Full Text PDFJ Inflamm Res
January 2025
Department of Shandong Trauma Center, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, 250014, People's Republic of China.
Background: Posttraumatic elbow stiffness is a complex complication with two characteristics of capsular contracture and heterotopic ossification. Currently, genomic mechanisms and pathogenesis of posttraumatic elbow stiffness remain inadequately understood. This study aims to identify differentially expressed genes (DEGs) and elucidate molecular networks of posttraumatic elbow stiffness, providing novel insights into disease mechanisms at transcriptome level.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!