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Shifting equilibria in a warming boreal forest.
Proc Natl Acad Sci U S A
January 2025
Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91011.
Pseudo-Phosphorylated Tau Forms Paired Helical Filaments in the Presence of High-Curvature Cholesterol-Containing Lipid Membranes.
J Am Chem Soc
January 2025
Department of Chemistry, Massachusetts Institute of Technology, 170 Albany Street, Cambridge, Massachusetts 02139, United States.
The tau protein misfolds in neurodegenerative diseases such as Alzheimer's disease (AD). These pathological tau aggregates are associated with neuronal membranes, but molecular structural information about how disease-like tau fibrils interact with the lipid membrane is scarce. Here, we use solid-state NMR to investigate the structure of a tau construct bearing four AD-relevant phospho-mimetic mutations (4E tau) with cholesterol-containing high-curvature lipid membranes, which mimic the membrane of synaptic vesicles in neurons.
View Article and Find Full Text PDFNuclear Magnetic Resonance Spectroscopy to Study Virus Structure.
Subcell Biochem
December 2024
IDIBE, Universidad Miguel Hernández, Elche, Alicante, Spain.
Nuclear magnetic resonance (NMR) is a spectroscopic technique based on the absorption of radiofrequency radiation by atomic nuclei in the presence of an external magnetic field. NMR has followed a "bottom-up" approach to solve the structures of isolated domains of viral proteins, including capsid protein subunits, or to provide information about other macromolecular partners with which such proteins interact. NMR has been instrumental in describing conformational changes in viral proteins and nucleic acids, showing the presence of dynamic equilibria which are thought to be important at different stages of the virus life cycle.
View Article and Find Full Text PDFEffects of initial vegetation heterogeneity on competition of submersed and floating macrophytes.
Math Biosci Eng
October 2024
U. S. Geological Survey, Wetland and Aquatic Research Center, Davie, USA.
Non-spatial models of competition between floating aquatic vegetation (FAV) and submersed aquatic vegetation (SAV) predict a stable state of pure SAV at low total available limiting nutrient level, , a stable state of only FAV for high , and alternative stable states for intermediate , as described by an S-shaped bifurcation curve. Spatial models that include physical heterogeneity of the waterbody show that the sharp transitions between these states become smooth. We examined the effects of heterogeneous initial conditions of the vegetation types.
View Article and Find Full Text PDFMolecular Investigation of SNAC as an Oral Peptide Permeation Enhancer in Lipid Membranes via Solid-State NMR.
Mol Pharm
January 2025
Pharmaceutical Sciences and Clinical Supply, Merck & Co., Inc., Rahway, New Jersey 07065, United States.
Oral peptide therapeutics are increasingly favored in the pharmaceutical industry for their ease of use and better patient adherence. However, they face challenges with poor oral bioavailability due to their high molecular weight and surface polarity. Permeation enhancers (PEs) like salcaprozate sodium (SNAC) have shown promise in clinical trials, achieving about 1% bioavailability.
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