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| http://dx.doi.org/10.1213/ANE.0000000000007249 | DOI Listing |
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Overactive Glutamatergic Basal Forebrain: Compensatory or Causal Mechanism in Cognitive Disorders.
Anesth Analg
February 2025
From the Department of Anesthesiology, Weill Cornell Medicine, New York, New York.
Memantine-induced functional rewiring of the glutamate synapse in the striatum of dopamine transporter knockout rats.
Br J Pharmacol
December 2024
Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.
Background And Purpose: Slow-acting biogenic amines, such as dopamine, are known to modulate fast neurotransmitters e.g. glutamate.
View Article and Find Full Text PDFPolish standard of treatment with racemic ketamine for patients with depressive disorders developed by a Working Group appointed by the National Consultant in the field of psychiatry.
Psychiatr Pol
June 2024
Uniwersytet Jagielloński Collegium Medicum, Wydział Lekarski, Klinika Psychiatrii Dorosłych.
The Polish standard of treatment with racemic ketamine for patients with depressive disorders was developed by a Working Group appointed by the National Consultant in the field of psychiatry. Despite the wide range of available medications, as many as one-third of depressed patients do not respond to standard antidepressant treatment, raising the need for an ongoing search for new effective and safe therapies. In recent years, the possible role of overactivity of the glutamatergic system in the etiopathogenesis of depression has again attracted the attention of many experts.
View Article and Find Full Text PDFUnveiling the molecular basis of lobeline's allosteric regulation of NMDAR: insights from molecular modeling.
Sci Rep
December 2023
Laboratory for Computational and Structural Biology, Jubilee Centre for Medical Research, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, 680005, India.
Neurological and psychiatric disorders contribute significantly to the global disease burden, adversely affecting the quality of life for both patients and their families. Impaired glutamatergic signaling is considered to be a major cause for most of the neurological and psychiatric disorders. Glutamate receptors are over activated in excitotoxic conditions, leading to dysregulation of Ca homeostasis, triggering the production of free radicals and oxidative stress, mitochondrial dysfunction and eventually cell death.
View Article and Find Full Text PDFArticle Synopsis
- Obsessive-compulsive disorder (OCD) affects 2% to 3% of the population and is characterized by unwanted thoughts and repetitive behaviors that lead to significant distress and functional impairment; it's associated with brain circuitry dysfunction and altered glutamate signaling.
- A study aims to evaluate the efficacy and safety of memantine, a glutamate-modulating drug, as an add-on treatment to a selective serotonin reuptake inhibitor in patients with moderate to severe OCD through a double-blind, randomized, placebo-controlled trial.
- The study will also explore memantine's effects on cognitive function and investigate how factors like gender and symptom subtypes influence treatment response.
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