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Cranberry prophylaxis in recurrent uncomplicated cystitis - avenues for advancement and clarification.
World J Urol
January 2025
Department of Urology, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong, 528000, People's Republic of China.
In Vivo Evidence for the Preventive Role of Vaccinium macrocarpon Aiton in Indomethacin-Induced Gastric Ulcer: Focusing on Antioxidant, Anti-Inflammatory and Anti-Apoptotic Mechanisms.
Vet Med Sci
January 2025
Department of Medical Pharmacology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
The present study aimed to unveil the gastroprotective potential of Vaccinium macrocarpon (VM) extract and its mechanism of action against indomethacin (INDO)-induced gastric ulcers in rats. To achieve this goal, rats were pretreated with either omeprazole (20 mg/kg) or VM (100 mg/kg) orally for 14 consecutive days. Gastric tissue samples were collected and various parameters were evaluated to understand the mechanism of VM's action, including the levels of superoxide dismutase, malondialdehyde, glutathione, CAT and transforming growth factor beta (TGF-β), as well as the mRNA expression levels of tumour necrosis factor alpha, interleukin 1 beta, nuclear factor kappa B (NF-κB) and inhibitor kappa B (IκB).
View Article and Find Full Text PDFBackground: Improving the efficiency of treatment and prevention of recurrent lower urinary tract infection (LUTI) is an important problem in modern urology. A significant role is given to the non-antibiotic measures.
Aim: To evaluate the clinical and microbiological efficiency of the drug Urolife-Next in patients with recurrent UTI.
Oral administration of cranberry-derived exosomes attenuates murine premature ovarian failure in association with changes in the specific gut microbiota and diminution in ovarian granulosa cell PANoptosis.
Food Funct
November 2024
Department of Gynaecology, Jingan Hospital of Traditional Chinese Medicine, Shanghai, China.
Article Synopsis
- A high-fat and high-sugar diet can lead to ovarian issues like ovarian insufficiency and premature ovarian failure, making treatment more challenging.
- Research was conducted on exosome-like nanovesicles derived from cranberries (Va-exos) to determine their effects on a mouse model with diet-induced ovarian failure, focusing on gut microbiota changes and ovarian cell health.
- Results showed that Va-exos improved symptoms of ovarian failure, enhanced gut barrier function, modulated gut microbiota, and decreased cell death in ovarian cells, suggesting a therapeutic role for cranberry-derived exosomes in treating diet-induced ovarian issues.
Flemish consensus statement on the prevention, diagnosis and treatment of urinary tract infections in older nursing home residents.
Acta Clin Belg
November 2024
Department of General Internal Medicine and Infectious Diseases, AZ Delta, Roeselare, Belgium.
Background: Urinary tract infections (UTIs) are one of the most commonly reported infections in Belgian nursing home residents. In older adults, UTI diagnosis and management is complex, often leading to over-diagnosis and irrational antimicrobial use, stressing the need for a guideline approach.
Objectives And Methods: A consensus statement on the prevention, diagnosis and treatment of UTIs in older adults residing in nursing homes was developed in a collaborative effort between the Flemish Hospital Outbreak Support Teams, the Flemish Agency for Care and Health, the Association of the Flemish Coordinating and Advising General Practitioners, the Belgian Association of Urology, the Belgian Society for Gerontology and Geriatrics and PhD researchers based on a combination of clinical expertise, (inter)national guidelines and peer-reviewed studies.
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