Hyaluronic acid filler treatment is increasingly prevalent in the realm of plastic surgery, serving to correct a range of facial changes resulting from aging. Nevertheless, with its expanded application, an uptick in complications has been observed. This article reported a 30-year-old female patient who received chin hyaluronic acid filler treatment 5 years ago started experiencing atrophy and progressive deterioration at the injection site a year ago. Currently, she presents with a pronounced depression beneath the left corner of her mouth, along with changes in skin tone and scarring. The patient exhibited progressive hemifacial atrophy within the region that had been injected with hyaluronic acid. Progressive hemifacial atrophy at the injection site may be a novel adverse effect associated with the injection of fillers, and it is important to be vigilant about this possibility.
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