Undernutrition has been identified as a significant public health challenge in developing nations like Tanzania. Severe childhood undernutrition is a life-threatening problem that can result in impaired growth, weakened immune systems, and even death. The primary aim of this study was to identify the prevalence of multiple forms of severe undernutrition and factors associated with the severity of childhood undernutrition in children aged 6-59 months in Tanzania. This was a secondary data analysis conducted on a cross-sectional survey obtained from the 2022 Tanzania Demographic and Health Survey Malaria Indicator Survey (TDHS-MIS). This analysis comprised 4224 children with complete information. The study employed the proportional odds model of ordinal logistic regression to identify factors associated with severity of stunting, wasting, and anemia. Out of the 4224 included children, 8.6% were severely stunted, 0.8% were severely wasted, and 1.7% were severely anemic. The prevalence of multiple forms of severe undernutrition was 10.4%. Significant associations were observed between socioeconomic factors-including the gender and age of the household head, household wealth status, possession of health insurance, and availability of mosquito nets with severe undernutrition. Maternal factors such as nutrition status, current age, age at first birth, education, marriage, and occupation were related to the severity of undernutrition. Approximately one children out of every 10 suffers from some form of severe undernutrition in Tanzania. Several factors including maternal and socioeconomic were identified as potentially influencing severe undernutrition. Multifaceted efforts are required to lessen the severity of undernutrition.
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http://dx.doi.org/10.1002/fsn3.4648 | DOI Listing |
Alzheimers Dement
January 2025
Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Introduction: Malnutrition correlates with neuropsychiatric symptoms (NPSs) in Alzheimer's disease (AD); however, the potential mechanism underlying this association remains unclear.
Methods: Baseline and longitudinal associations of nutritional status with NPSs were analyzed in 374 patients on the AD continuum and 61 healthy controls. Serum biomarkers, behavioral tests, cerebral neurotransmitters, and differentially gene expression were evaluated in standard and malnourished diet-fed transgenic APPswe/PSEN1dE9 (APP/PS1) mice.
Int J Chron Obstruct Pulmon Dis
January 2025
Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Background: This study aims to investigate the association between vitamin D levels and the risk of severe acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
Methods: We conducted a prospective observational study with 636 COPD patients admitted for exacerbations between January 2021 and December 2022. Patients were categorized based on serum 25-hydroxyvitamin D levels: severe deficiency (<10 ng/mL), deficiency (10-20 ng/mL), insufficiency (20-30 ng/mL), or sufficiency (>30 ng/mL).
Hosp Pediatr
January 2025
Departments of Medicine and Ethics, University of Vermont Medical Center, Burlington, Vermont.
Severe eating disorders (EDs) are a common and increasing threat to normal adolescent health and development. Major clinical challenges include longstanding malnutrition potentially complicated by emergent electrolyte disorders and cardiac dysfunction. The care of adolescents with severe EDs can lead to challenging decisions regarding the initiation of involuntary feeding with restraints.
View Article and Find Full Text PDFCalcif Tissue Int
January 2025
Endocrinology Department, School of Medicine, Pontificia Universidad Católica de Chile, Av. Diagonal Paraguay 262, Cuarto Piso, Santiago, Chile.
X-linked hypophosphatemia (XLH) is a rare metabolic disorder characterized by elevated FGF23 and chronic hypophosphatemia, leading to impaired skeletal mineralization and enthesopathies that are associated with pain, stiffness, and diminished quality of life. The natural history of enthesopathies in XLH remains poorly defined, partly due to absence of a sensitive quantitative tool for assessment and monitoring. This study investigates the utility of 18F-NaF PET/CT scans in characterizing enthesopathies in XLH subjects.
View Article and Find Full Text PDFClin Neurol Neurosurg
January 2025
Department of Neurosurgery, Zucker School of Medicine at Hofstra, Long Island Jewish Medical Center and North Shore University Hospital, Northwell Health, Manhasset, NY, United States.
Background: Malnutrition is a predictor of poor surgical outcomes, but its specific effects in spinal epidural abscess (SEA) are understudied. This study aims to assess the association between nutritional status and post-operative outcomes.
Methods: We conducted a retrospective cohort study using the 2011-2022 American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) database to identify adult SEA patients who underwent spinal surgery.
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