A rare injection site reaction known as Nicolau syndrome can occur in patients receiving subcutaneous immunotherapy. This syndrome has been reported only a handful of times in the literature related to subcutaneous immunotherapy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11719306PMC
http://dx.doi.org/10.1016/j.jacig.2024.100375DOI Listing

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