Demoralization in the face of adversity is a common existential state. However, it has not been examined in reaction to warfare, and the mediators between the extent of exposure to war and demoralization in this context are also unknown. This study explored the associations of indirect exposure to war, acute stress symptoms, disengaged coping, and demoralization. Additionally, it examined the serial mediation of acute stress symptoms and disengaged coping in the relationship between indirect exposure to war and demoralization. The survey was conducted 4 weeks after the 7 October war broke out and included 393 Israeli citizens (women and men, Jews and Arabs) indirectly affected by the threatening situation in Israel. Questionnaires measured acute stress symptoms, disengaged coping, and demoralization. War-related exposure and demographic data were collected. The analysis revealed that the higher the indirect exposure to war, the higher the acute stress symptoms, use of disengaged coping, and demoralization. Additionally, individuals with acute stress disorder had higher demoralization. The serial mediation model showed partial mediation: acute stress symptoms and the use of disengaged coping mediated the relationships between indirect exposure to war and demoralization (although the direct association between the extent of exposure and demoralization remained significant). In the face of traumatic events, such as warfare, professionals should identify individuals with high levels of acute stress symptoms and provide help to reduce the use of disengaged coping and long-term negative consequences such as demoralization.
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http://dx.doi.org/10.1080/20008066.2024.2449308 | DOI Listing |
Pharmacol Rep
January 2025
Experimental Medicine Research Center, Tehran University of Medical Sciences, P.O. Box: 13145-784, Tehran, Iran.
Background: Epilepsy, a neurological disorder characterized by recurrent seizures, presents considerable difficulties in treatment, particularly when dealing with drug-resistant cases. Dapsone, recognized for its anti-inflammatory properties, holds promise as a potential therapeutic option. However, its effectiveness in epilepsy requires further investigation.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
Herbicides such as paraquat (PQ) are frequently utilized particularly in developing nations. The present research concentrated on the pulmonary lesions triggered by PQ and the beneficial effect of the angiotensin receptor neprilysin inhibitor (ARNI), sacubitril/valsartan, against such pulmonary damage. Five groups of rats were established: control, ARNI, PQ (10 mg/kg), ARNI 68 + PQ, and ARNI 34 + PQ.
View Article and Find Full Text PDFIntensive Care Med
January 2025
Center for Disease Mechanisms Research, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.
Purpose: Major cardiovascular surgery imposes high physiologic stress, often causing severe organ dysfunction and poor outcomes. The underlying mechanisms remain unclear. This study investigated metabolic changes induced by major cardiovascular surgery and the potential role of identified metabolic signatures in postoperative acute kidney injury (AKI).
View Article and Find Full Text PDFPain
January 2025
Department of General Internal Medicine and Psychosomatics, Heidelberg University, Heidelberg, Germany.
This study investigates the associations between early childhood adversities, stress perception, and fibromyalgia syndrome (FMS). Although the interconnection between dysregulated stress systems and FMS is well documented, the interconnection between early adversities and FMS remains less understood. This study explores the relationship of early-life stress and FMS by examining its mediation through perceived stress, and acute and chronic endocrine stress indicators.
View Article and Find Full Text PDFTrauma Surg Acute Care Open
January 2025
CEO, Crowell Global Advisors, Washington, District of Columbia, USA.
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