Wolff (2024) takes a comparative phylogenetic approach to study the evolution of dragline silk in 164 species of spiders, including both araneid and non-araneid species. Many structural and mechanical properties of dragline silk showed no correlations; however, both tensile strength and toughness correlated with birefringence-an indicator for the directional ordering of protein materials in the silk fibre. These properties do not seem to differ between web-building and non-web-building spiders; many spider families were found to include species that produce super-performing silk as well as species that produce weak-performing silk.
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http://dx.doi.org/10.1093/evolut/qpaf002 | DOI Listing |
Plant J
January 2025
Biomacromolecules Research Team, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.
Spider silk, especially dragline silk from golden silk spiders (Trichonephila clavipes), is an excellent natural material with remarkable mechanical properties. Many studies have focused on the use of plants as biofactories for the production of recombinant spider silk. However, the effects of this material on the mechanical properties or physiology of transgenic plants remain poorly understood.
View Article and Find Full Text PDFEvolution
January 2025
School of Environmental and Life Sciences (SELS), Faculty of Science and Health, University of Portsmouth, United Kingdom.
Wolff (2024) takes a comparative phylogenetic approach to study the evolution of dragline silk in 164 species of spiders, including both araneid and non-araneid species. Many structural and mechanical properties of dragline silk showed no correlations; however, both tensile strength and toughness correlated with birefringence-an indicator for the directional ordering of protein materials in the silk fibre. These properties do not seem to differ between web-building and non-web-building spiders; many spider families were found to include species that produce super-performing silk as well as species that produce weak-performing silk.
View Article and Find Full Text PDFBiomacromolecules
January 2025
Shanghai Engineering Research Center of Molecular Therapeutics & New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.
Spider silk is renowned for its exceptional toughness, with the strongest dragline silk composed of two proteins, MaSp1 and MaSp2, featuring central repetitive sequences and nonrepetitive terminal domains. Although these sequences to spider silk's strength and toughness, the specific roles of MaSp1 and MaSp2 at the atomic level remain unclear. Using AlphaFold3 models and molecular dynamics (MD) simulations, we constructed models of MaSp1 and MaSp2 and validated their stability.
View Article and Find Full Text PDFAdv Healthc Mater
December 2024
Department of Biomedical Engineering, City University of Hong Kong, Kowloon, Hong Kong SAR, 999077, China.
The advent of bionic skin sensors represents a significant leap forward in the realm of wearable health monitoring technologies. Existing bionic skin technologies face several limitations, including complex and expensive manufacturing processes, low wearing comfort, and challenges in achieving comfortable real-time health monitoring. These shortcomings hinder the widespread adoption and practical utility of bionic skin in various applications.
View Article and Find Full Text PDFCommun Chem
November 2024
Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
Liquid-liquid phase separation (LLPS) of proteins can be considered an intermediate solubility regime between disperse solutions and solid fibers. While LLPS has been described for several pathogenic amyloids, recent evidence suggests that it is similarly relevant for functional amyloids. Here, we review the evidence that links spider silk proteins (spidroins) and LLPS and its role in the spinning process.
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