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http://dx.doi.org/10.48095/ccachp2024136 | DOI Listing |
Cureus
November 2024
Department of Orthopedics and Traumatology, Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", Bucharest, ROU.
This study aims to evaluate the osteoconductive and osteoinductive potential of novel composite collagenous sponges enriched with keratin (K), hydroxyapatite (HA), and their combination (K+HA) for osteochondral regeneration in rat knee models. By examining cell proliferation, mineralization, and vascularization, we aim to determine the regenerative effectiveness of these materials in promoting osteochondral repair, particularly in load-bearing joints like the knee. Addressing the problem of osteochondral defects (OCD), which lead to osteoarthritis-a condition characterized by pain and functional impairment-the hereby research evaluates these biomaterials for their potential to foster bone and cartilage repair, especially in load-bearing joints as the knee.
View Article and Find Full Text PDFProc Biol Sci
December 2024
Department of Animal Science and Biotechnology, School of Veterinary Medicine, Azabu University, 1-17-71, Fuchinobe, Sagamihara, Kanagawa 252-5201, Japan.
Emotional contagion occurs in many animals, including rodents. To determine the social signals of emotional state-matching between individuals in mice, we conducted an empirical laboratory experiment using visual, olfactory and auditory stimuli. The Japanese wild-derived mouse strain MSM/Ms (MSM) was tested as observers, since our initial experiments indicated that MSM mice showed higher sensitivity to others' pain compared with the laboratory strain C57BL/6J (B6).
View Article and Find Full Text PDFDigit Health
December 2024
Department of Research & Development, MyOr Diagnostics Ltd., Zichron Yaakov, Israel.
Adv Ther (Weinh)
September 2024
Department of Mechanical Engineering, University of Connecticut, United States.
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are one of the most effective treatments for obesity. The current therapy associated with repeated subcutaneous injections to maintain the drug therapeutic effect causes patient compliance issues and raises environmental concerns (due to sharp biohazard waste from disposed syringes/needles). Herein, we report a programmable scheduled release microneedles (PSR-MNs) system for delivering Semaglutide (a GLP-1 RA agent with a half-life of ~ 7 days) to manage and treat obesity.
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