Graph Neural Networks (GNNs) have received extensive research attention due to their powerful information aggregation capabilities. Despite the success of GNNs, most of them suffer from the popularity bias issue in a graph caused by a small number of popular categories. Additionally, real graph datasets always contain incorrect node labels, which hinders GNNs from learning effective node representations. Graph contrastive learning (GCL) has been shown to be effective in solving the above problems for node classification tasks. Most existing GCL methods are implemented by randomly removing edges and nodes to create multiple contrasting views, and then maximizing the mutual information (MI) between these contrasting views to improve the node feature representation. However, maximizing the mutual information between multiple contrasting views may lead the model to learn some redundant information irrelevant to the node classification task. To tackle this issue, we propose an effective Contrastive Graph Representation Learning with Adversarial Cross-view Reconstruction and Information Bottleneck (CGRL) for node classification, which can adaptively learn to mask the nodes and edges in the graph to obtain the optimal graph structure representation. Furthermore, we innovatively introduce the information bottleneck theory into GCLs to remove redundant information in multiple contrasting views while retaining as much information as possible about node classification. Moreover, we add noise perturbations to the original views and reconstruct the augmented views by constructing adversarial views to improve the robustness of node feature representation. We also verified through theoretical analysis the effectiveness of this cross-attempt reconstruction mechanism and information bottleneck theory in capturing graph structure information and improving model generalization performance. Extensive experiments on real-world public datasets demonstrate that our method significantly outperforms existing state-of-the-art algorithms.
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http://dx.doi.org/10.1016/j.neunet.2024.107094 | DOI Listing |
J Thorac Oncol
January 2025
Division of Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan.
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View Article and Find Full Text PDFBiomolecules
January 2025
School of Artificial Intelligence, Anhui University, Hefei 230601, China.
Interleukin-6 (IL-6) is a potent glycoprotein that plays a crucial role in regulating innate and adaptive immunity, as well as metabolism. The expression and release of IL-6 are closely correlated with the severity of various diseases. IL-6-inducing peptides are critical for the development of immunotherapy and diagnostic biomarkers for some diseases.
View Article and Find Full Text PDFDiagn Pathol
January 2025
Department of Pathology, Kasturba Medical College, India, Manipal, 576104.
Background: Muscle-invasive bladder carcinomas (MIBCs) exhibit significant heterogeneity, with diverse histopathological features associated with varied prognosis and therapeutic response. Although genomic profiling studies have identified several molecular subtypes of MIBC, two basic molecular subtypes are identified - luminal and basal, differing in biological behaviour and response to treatment. As molecular subtyping is complex, surrogate immunohistochemical (IHC) markers have been used to determine the molecular subtypes with good correlation to genomic profiling.
View Article and Find Full Text PDFHypertension is a critical risk factor and cause of mortality in cardiovascular diseases, and it remains a global public health issue. Therefore, understanding its mechanisms is essential for treating and preventing hypertension. Gene expression data is an important source for obtaining hypertension biomarkers.
View Article and Find Full Text PDFJ Imaging
January 2025
Clinic of Medicine, Nord-Trøndelag Hospital Trust, Levanger Hospital, 7601 Levanger, Norway.
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a cornerstone in minimally invasive thoracic lymph node sampling. In lung cancer staging, precise assessment of lymph node position is crucial for clinical decision-making. This study aimed to demonstrate a new deep learning method to classify thoracic lymph nodes based on their anatomical location using EBUS images.
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